Reducing Friability of Tablets for Film Coating by Using Ceolus KG-1000
In the tablet film coating process, especially when it comes to large tablets especially with the size more than ø9mm, friability can be an issue at the early stage of the process. The purpose of the experiment was to confirm if Ceolus™ KG-1000, Asahi Kasei’s Microcrystalline Cellulose (“MCC”) with the highest compactibility out of our product lineup, can reduce the friability of tablets for film coating, through the comparison of three different MCC grades.
The objective of the study is to clarify whether Ceolus™ KG-1000, can reduce the friability of tablet cores in a coating process. The target friability criteria are less than 0.2%. Check the full paper by clicking on the picture:
Conclusion
The study confirms that in the film coating process the tablets friability can be reduced by adding 5% of Ceolus™ KG-1000, in the formulation. High tablet hardness & low friability of tablet cores containing Ceolus™ KG-1000, contributes to achieve low friability in tablet coating, KG-1000 is excellent in maintaining of tablets edges, KG-1000 can be recommended as a problem solver for the friability issue in tablet coating.
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