Impact of Formulation design and Lyophilization on the Physicochemical Characteristics of Finasteride Nanosystems
Aim
The fundamental purpose of this study was to develop a stable lyophilized finasteride nanosystem (FNS-NS) for topical delivery.
Methods
The FNS-NS was fabricated using an ultrasonication technique. The impact of two different cryoprotectants on the physicochemical characteristics of FNS-NS before and after lyophilization was thoroughly investigated.
Results
The lyophilized FNS-NS had spherical shape with particle size lied between 160.23nm ± 0.32 to 294.2nm ± 9.73, low PDI values (0.16 ± 0.02 to 0.41 ± 0.07) and zeta potential ranging from -31.76mV to +56.3mV. The confocal laser microscopy depicted a comparatively higher cellular internalization achieved for undecorated FNS-NS with respect to its chitosan-decorated counterpart.
Conclusion
The lyophilized FNS-NS was stable for 90 days at proper storage conditions. The FNS-NS with 15% trehalose had appropriate physicochemical attributes that could be a promising carrier for topical delivery to treat androgenic alopecia.
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