Virodex™: exploring our innovative solution to the Triton™ X-100 ban
Triton™ X-100 is a widely used non-ionic surfactant and emulsifier, with a range of applications including viral inactivation, cell lysis and protein solubilisation. Triton™ X-100 belongs to the substance group Phenol ethoxylates which are considered to be hazardous to the aquatic environment and a known endocrine disruptor1. As a result Phenol ethoxylates were first added to the Candidate List of Substances of Very High Concern of the REACH (Registration, Evaluation and Restriction of Chemicals) Regulation in 2012 by the European Chemicals Agency2. In 2017 the European Parliament approved the REACH vote to place Triton™ X-100 onto Annex XIV of the REACH regulation. Its sunset date was set as January 4th 2021, banning its use and sale in the EU except for those with an exemption certificate3.
Triton™ X-100 is a widely used non-ionic surfactant and emulsifier, with a range of applications including viral inactivation, cell lysis and protein solubilisation. Triton™ X-100 belongs to the substance group Phenol ethoxylates which are considered to be hazardous to the aquatic environment and a known endocrine disruptor1. As a result Phenol ethoxylates were first added to the Candidate List of Substances of Very High Concern of the REACH (Registration, Evaluation and Restriction of Chemicals) Regulation in 2012 by the European Chemicals Agency2. In 2017 the European Parliament approved the REACH vote to place Triton™ X-100 onto Annex XIV of the REACH regulation. Its sunset date was set as January 4th 2021, banning its use and sale in the EU except for those with an exemption certificate3.
Learn about our Virodex™ range of products
Our Virodex™ range of product offerings for viral inactivation and cell lysis are REACH-compliant, compendial compliant, cGMP EXCiPACT manufactured, sustainable chemicals that have been optimised for use in the biomanufacturing industry for uses in recombinant proteins, blood fractionation products, viral proteins, viral vectors including AAVs, and more.
Under our Virodex™ range, we currently offer two distinct, well-studied chemistries:
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Source: Croda, website https://www.crodapharma.com/en-gb/news-and-blog/triton-x-100-virodex
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