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Ocular Delivery
Ocular Implants for Drug Delivery: Improving Patient Outcomes
Did you know that there are already 11 ocular implants on the market and over 30 in development? (See Table 1 and Figure 2). Every year, more and more people live with eye disease or vision impairment of some kind, requiring treatment to avoid additional vision loss or blindness.
In 2010,…
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Studies on Formulation and Evaluation of Eudragit RS PO Based Nanoparticulate System of Aceclofenac…
Aim: Ocular drug delivery is the most challenging and interesting goal in front of the pharmaceutical scientist. Ocular inflammation is the most commonly affecting disease of the eye. The objectives of present investigation were to formulate and evaluate eudragit RS PO (ERS PO) based Aceclofenac…
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Combination of Nanomicellar Technology and In Situ Gelling Polymer as Ocular Drug Delivery System…
A combination of in situ gelling systems and a loaded drug self-assembling nanomicellar carrier was chosen in this study as a new potential Ocular Drug Delivery System (ODDS) for Cyclosporine-A (CyA), a poorly water-soluble drug. Two non-ionic surfactants (d-α-tocopherol polyethylene glycol…
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A grafted copolymer-based nanomicelles for topical ocular delivery of everolimus: Formulation,…
Treatment of posterior uveitis via topical route is desirable but cannot be achieved by conventional drug delivery strategies. Therefore, the aim of this study is to develop a topical nanomicellar formulation of an immunosuppressant drug, everolimus using Soluplus®, a grafted copolymer of polyvinyl…
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A review of nanocarrier mediated drug delivery systems for posterior segment eye disease: challenges…
Posterior segment eye disease is a leading cause of irreversible vision impairment and blindness. As the unique organ for vision, eyes are protected by various protective barriers. The existence of physiological barriers and elimination mechanisms makes it challenging to treat the posterior segment…
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Biopolymer-based nanoparticles with tunable mucoadhesivity efficiently deliver therapeutics across…
To overcome the natural barriers of the ocular system that limit the topical delivery of therapeutically active molecules to the posterior eye, nanoscale drug carriers can be used to improve transcorneal drug transport. So far, using mucoadhesive drug carriers has been put forward as the most…
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Novel liposome-based and in situ gelling artificial tear formulation for dry eye disease treatment
14. December 2017
Purpose
Artificial tears are widely used in the treatment of dry eye disease, although current formulations do not closely resemble natural tears. The purpose of this study was the design and characterization of a novel in situ gelling artificial tear formulation,…
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