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Ocular Delivery
Microneedles for advanced ocular drug delivery
In the field of ocular drug delivery, topical delivery remains the most common treatment option for managing anterior segment diseases, while intraocular injections are the current gold standard treatment option for treating posterior segment diseases. Nonetheless, topical eye drops are associated…
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Development, evaluation and recent progress of ocular in situ gelling drug delivery vehicle based on…
Abstract
The fabrication of an effective in situ gelling ophthalmic drug delivery vehicle is recently received enormous interest to overcome the demerits of conventional ocular solutions and achieve desired therapeutic efficacy. Poloxamer 407 and poloxamer 188 are among the most commonly used…
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Breaking the ocular barrier through nano-lipid carriers to treat intraocular diseases
Abstract
The human eye is a special organ. Its defense mechanisms protect it from invading microbes and harmful molecules. Treatment of different eye diseases often shows poor results due to the presence of these barriers. Nano lipid carriers have the capability to overcome these anatomical and…
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Challenges and strategies for ocular posterior diseases therapy via non-invasive advanced drug…
Posterior segment diseases, such as age-related macular degeneration (AMD) and diabetic retinopathy (DR) are vital factor that seriously threatens human vision health and quality of life, the treatment of which poses a great challenge to ophthalmologists and ophthalmic scientists. In particular,…
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Long-acting microneedle formulations
The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into the dermal and ocular space, but they can also control the release profile of the active…
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Innovative Strategies for Drug Delivery to the Ocular Posterior Segment
Innovative and new drug delivery systems (DDSs) have recently been developed to vehicle treatments and drugs to the ocular posterior segment and the retina. New formulations and technological developments, such as nanotechnology, novel matrices, and non-traditional treatment strategies, open new…
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Nanomaterial-based ophthalmic drug delivery
The low bioavailability and side effects of conventional drugs for eye disease necessitate the development of efficient drug delivery systems. Accompanying the developments of nanofabrication techniques, nanomaterials have been recognized as promising tools to overcome these challenges due to their…
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Ocular application of electrospun materials for drug delivery and cellular therapies
The constraints of delivering conventional drugs, biologics and cell-based therapeutics to target ocular sites necessitate the fabrication of novel drug delivery systems to treat diverse ocular diseases. Conventional ocular drug delivery approaches are prone to low bioavailability, poor penetration…
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Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye…
Chronic ocular diseases can seriously impact the eyes and could potentially result in blindness or serious vision loss. According to the most recent data from the WHO, there are more than 2 billion visually impaired people in the world. Therefore, it is pivotal to develop more sophisticated,…
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Binary Polymeric Surfactant Mixtures for the Development of Novel Loteprednol Etabonate Nanomicellar…
The treatment of several ocular inflammatory conditions affecting different areas of the ocular globe involves the administration of topical ophthalmic formulations containing corticosteroids. This research was aimed at evaluating the solubilising efficacy of 5.0% w/w of different binary mixtures of…
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