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Ocular Delivery
In-situ tear fluid dissolving nanofibers enable prolonged viscosity-enhanced dual drug delivery to…
Liquid and semi-solid formulations are the most commonly used drug delivery systems for ophthalmic diseases. Upon application into the conjunctival sac, these systems introduce a variable and unphysiologically high liquid volume to the eye, resulting in overflow and extensive nasolacrimal drainage,…
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PMC Isochem – Your partner for Smart & Innovative Solutions
See in the following a part of the company brochure by PMC Isochem
PMC Isochem offers Drug Delivery solutions, CDMO services and Active Pharmaceutical Ingredients and intermediates:
From development to GMP production of Amphiphilic and hydrophilic polymers for pharmaceutical…
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Vitamin E TPGS by PMC Isochem
D-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) has been approved as a safe pharmaceutical adjuvant by FDA, and several drug delivery systems (DDS) based on TPGS have been developed. TPGS hase interesting properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in…
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Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems
Mucus gel constitutes of heavily cross-linked mucin fibers forming a viscoelastic, dense porous network that coats all the exposed epithelia not covered with the skin. The layer provides protection to the underlying gastrointestinal, respiratory, and female reproductive tracts, in addition to the…
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Ciprofloxacin-Loaded Zein/Hyaluronic Acid Nanoparticles for Ocular Mucosa Delivery
Bacterial conjunctivitis is a worldwide problem that, if untreated, can lead to severe complications, such as visual impairment and blindness. Topical administration of ciprofloxacin is one of the most common treatments for this infection; however, topical therapeutic delivery to the eye is quite…
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PLGA-modified Syloid®-based microparticles for the ocular delivery of terconazole: in-vitro and…
The eye is an invulnerable organ with intrinsic anatomical and physiological barriers, hindering the development of a pioneer ocular formulation. The aim of this work was to develop an efficient ocular delivery system that can augment the ocular bioavailability of the antifungal drug, terconazole.…
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Hyaluronic Acid: Its Versatile Use in Ocular Drug Delivery with a Specific Focus on Hyaluronic…
Extensive research is currently being conducted into novel ocular drug delivery systems (ODDS) that are capable of surpassing the limitations associated with conventional intraocular anterior and posterior segment treatments. Nanoformulations, including those synthesised from the natural,…
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The Use of Polymer Blends in the Treatment of Ocular Diseases
The eye is an organ with limited drug access due to its anatomical and physiological barriers, and the usual forms of ocular administration are limited in terms of drug penetration, residence time, and bioavailability, as well as low patient compliance. Hence, therapeutic innovations in new drug…
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Non-invasive drug delivery systems mediated by nanocarriers and molecular dynamics simulation for…
Local deliver medication in a non-invasive pattern and attaining a long-term sustained release at ocular regions to minimize side effects is fascinating for treatment and precision medicine, but its rational design remains a challenge. The aim of this study was to analyze the effect of different…
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Development and optimization of solid lipid nanoparticles coated with chitosan and…
Many formulation strategies have been employed to improve ocular bioavailability of topical eye drops. The aim of this study was to develop and evaluate a series of solid lipid nanoparticles coated with poly(2-ethyl-2-oxazoline) and chitosan for ocular delivery of ciprofloxacin. Ciprofloxacin-loaded…
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