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Ocular Delivery
Thiolated Hydroxypropyl-β-cyclodextrin: A Potential Multifunctional Excipient for Ocular Drug…
The goal of this study was the design and evaluation of a thiolated cyclodextrin providing high drug solubilizing and mucoadhesive properties for ocular drug delivery. Hydroxypropyl-β-cyclodextrin (HP-β-CD) was thiolated via a microwave-assisted method, resulting in a degree of thiolation of 33%.…
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Overcoming Challenges in Ophthalmic Formulations through Polymer Selection – A Closer Look at…
Ophthalmic drug formulations are growing in importance due to the increased prevalence of eye-related
disorders such as diabetic retinopathy and macular degeneration.However, ocular drug delivery is challenging due to unique anatomical and physiological barriers such as pre-corneal loss factors…
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Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular…
Nanostructured lipid carriers (NLC) are novel lipidic nanosystems that provide significant improvements in terms of high drug loading capacity and controlled drug release. The purpose of the present work was based on the design, development, and physicochemical characterization of lactoferrin-loaded…
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Application of Vitamin E TPGS in ocular therapeutics – Attributes beyond excipient
Diseases affecting the anterior segment and the external surface of the eye are usually treated by drugs applied topically. The formulations designed for this purpose are developed to deliver active pharmaceutical agents to the eye optimally. These formulations are prepared by adding various agents…
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Micelles based on polyvinylpyrrolidone VA64: A potential nanoplatform for the ocular delivery of…
Purpose of this work was to determine the feasibility of a nano-ophthalmic solution consisting of the nanocarrier polyvinylpyrrolidone VA64 (VA64) and encapsulated apocynin (APO) as treatment for ocular inflammatory diseases. Results showed the solution, termed APO-VA64 ophthalmic solution, could be…
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The Effect of Polymers on Drug Release Kinetics in Nanoemulsion In Situ Gel Formulation
Glaucoma is an ocular condition characterized by elevated intraocular pressure (IOP). Conventional treatments of glaucoma face poor corneal permeability and bioavailability. To address these issues, a nanoemulsion in situ gel of Timolol maleate was developed in this study by adding the polymer…
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Formulation, optimization and evaluation of vitamin E TPGS emulsified dorzolamide solid lipid…
Herein, we designed this research to develop dorzolamide (DRZ) encapsulated solid lipid nanoparticles (SLNs) for ocular administration. The DRZ-SLNs were fabricated by ultrasonic emulsification method and optimized statistically by Box-Behnken design (3 factors at three levels BBD). Glyceryl…
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Lipid Nanoparticles for the Posterior Eye Segment
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior…
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Preparation and Functional Evaluation of Electrospun Polymeric Nanofibers as a New System for…
Due to the rapid clearance of external agents from the surface of the cornea, conventional ocular formulations usually require frequent and long duration of administration to achieve a therapeutic level of the drug on the cornea which can be conquered using prolonged-release nanofibrous inserts. In…
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Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge…
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