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Ocular Delivery
Formulation, characterization, optimization and in-vivo evaluation of methazolamide liposomal…
The rationale of this study was to formulate topically effective sustained release ophthalmic Methazolamide (MTA) liposomal in-situ gel. Lipid film hydration method was employed for the preparation of MTA liposomes consisting of lecithin and cholesterol. Optimization of the MTA liposomes by…
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Recent trends in nanocarrier based approach in the management of dry eye disease
Dry eye disease (DED) represents a major public health issue worldwide. Conventional ophthalmic preparations usually have a short pre-corneal residence time, require frequent and prolonged administration of drugs, lead to poor medication adherence. Nanocarriers because of their unique structural and…
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Ophthalmic Nanoemulsions: From Composition to Technological Processes and Quality Control
Nanoemulsions are considered as the most promising solution to improve the delivery of ophthalmic drugs. The design of ophthalmic nanoemulsions requires an extensive understanding of pharmaceutical as well as technological aspects related to the selection of excipients and formulation processes.…
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Topical ocular delivery of vancomycin loaded cationic lipid nanocarriers as a promising and…
Vancomycin (VCM) is a drug of choice for treating infections caused by Staphylococcus species, reported being the most causative agent of bacterial endophthalmitis. However, the ocular bioavailability of topically applied VCM is low due to its high molecular weight and hydrophilicity. The current…
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Modulated approaches for strategic transportation of proteins and peptides via ocular route
The influence of macromolecules in major eye disorders including retinal neovascularization, retinopathy, age-related macular degeneration, choroidal neovascularization, etc. offers substantial advantages in the development of formulations, designing of new delivery approaches, and setting of new…
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Development of Chitosan/Cyclodextrin Nanospheres for Levofloxacin Ocular Delivery
Levofloxacin (LVF) is an antibacterial drug approved for the treatment of ocular infections. However, due to the low ocular bioavailability, high doses are needed, causing bacterial resistance. Polymeric nanospheres (NPs) loading antibiotic drugs represent the most promising approach to eradicate…
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Dexamethasone-Loaded Nanostructured Lipid Carriers for the Treatment of Dry Eye Disease
Dry eye disease (DED) or keratoconjunctivitis sicca is a chronic multifactorial disorder of the ocular surface caused by tear film dysfunction. Symptoms include dryness, irritation, discomfort and visual disturbance, and standard treatment includes the use of lubricants and topical steroids.…
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Ocular Distribution of Papaverine Using Non-aqueous Vehicles
Papaverine, a poorly soluble opium alkaloid, has recently been shown to reduce retinal inflammation due to which it may have therapeutic application in the management of Leber’s hereditary optic neuropathy. In this study, papaverine eyedrops based on medium chain triglycerides were prepared and the…
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In vivo drug delivery via contact lenses: The current state of the field from origins to present
Over the past half century, contact lenses have been investigated for their potential as drug delivery devices for ocular therapeutics. Hundreds of studies have been published in the pursuit of the most effective and efficient release strategies and methods for contact lens drug delivery.
This…
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Formulation and Evaluation of Thermosensitive Flurbiprofen In Situ Nano Gel for the Ocular Delivery
The contemporary research implicates the formulation and evaluation of a thermosensitive in situ nano gelling method to improve solubility and ocular residence time of flurbiprofen. This study was carried out in two phases. In the first phase, an insolubility drug has been formulated in the form of…
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