Oils have been used by the pharmaceutical industry for decades. From parenteral nutrition to soft gel formulations, oils play a key role in a wide range of pharmaceutical products. With an ever increasing number of new drug candidates with poor aqueous solubility and poor oral bioavailability, oils are very attractive candidates to solve real challenges for the formulators.
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Pharmaceutical Oils
Enhanced oral bioavailability of rutin by a self-emulsifying drug delivery system of an extract of…
The aim of this study was to develop and optimize a self-emulsifying drug delivery system (SEDDS) containing an extract of calyces from Physalis peruviana with high mucus permeating properties to increase the bioavailability and the hypoglycemic activity of the active metabolites of the extract. The…
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Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil…
Mesoporous silica microparticles functionalized with lactose for the specific release of essential oil components (EOCs) in the small intestine are presented. In vitro and in vivo intestinal models were applied to validate the microparticles (M41-EOC-L), in which the presence of lactase acts as the…
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Formulation design, production and characterisation of solid lipid nanoparticles (SLN) and…
Lipid nanoparticles have been widely investigated for their use as either carriers for poorly water soluble actives or as (Pickering) emulsion stabilisers. Recent studies have suggested that the fabrication of lipid nanostructures that can display both these performances concurrently, can enable the…
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Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates…
Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation. However, this natural oil-based formulation also leads to considerable variability in absorption of CBD. In this work, the performance of…
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Comparison of Three Different Aqueous Microenvironments for Enhancing Oral Bioavailability of…
Background: The purpose of this study was to screen various drug delivery systems for improving the aqueous solubility and oral bioavailability of sildenafil. Three representative techniques, solid self-nanoemulsifying drug delivery systems (SNEDDS), amorphous microspheres and crystalline…
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Self-dispersing self-assembling systems for controlled oral delivery of gliclazide
Self-microemulsifying systems undergo self-dispersion to form microemulsion with subsequent self-assembly to form liquid crystalline (LC) and/or gel phases. These transitions modulate the release and absorption pattern of loaded drug. Accordingly, the primary objective was to evaluate these phases…
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Lipid Based Formulations in Hard Gelatin and HPMC Capsules: A Physical Compatibility Study
Purpose
To investigate the compatibility between hard gelatin and HPMC capsules with a range of different isotropic lipid based formulations containing multiple excipients.
Methods
The miscibility was investigated for 350 systems applying five different oils (Labrafac ™ lipophile WL1349, Maisine®…
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