Oils have been used by the pharmaceutical industry for decades. From parenteral nutrition to soft gel formulations, oils play a key role in a wide range of pharmaceutical products. With an ever increasing number of new drug candidates with poor aqueous solubility and poor oral bioavailability, oils are very attractive candidates to solve real challenges for the formulators.
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Pharmaceutical Oils
Pharmaceutical oils for Cannabinoid drug products from ADM-SIO
Medicinal Cannabinoids
There are currently more than 150 cannabinoid-based products under development in the world. The first US FDA approved product Epidiolex®, isolated from the cannabis plant and indicated for severe forms of epilepsy is formulated with Sesame oil. Other approved products like…
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Oil adsorption – The Interview with Fuji Chemical
Fuji Chemical Industries specializes in producing porous spray-dried excipients for the pharmaceutical and nutraceutical markets. They spray-dry their excipients to produce free-flowing granules and unique internal structures that enhance compressibility and functionality. These structures are ideal…
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Boost your drug bioavailability with Labrafac™ MC60
Gattefossé widens its range of high quality, functional excipients for oral bioavailability enhancement with Labrafac™ MC60, glycerol monocaprylocaprate. Labrafac™ MC60 is used for oral bioavailability enhancement of poorly water-soluble, poorly permeable drugs.
Glycerol monocaprylocaprate is a…
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Innovate in bi-gel with Emulfree® Duo
Discover Gattefossé's brand new excipient Emulfree® Duo, a ready-to-use stabilizing agent, enabler of bi-gel, an emerging topical dosage form.
Bi-gels consist of an intimate mixture of aqueous and oily gels. Thanks to their dual nature, they are associated with better drug absorption through the…
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Preparation and Evaluation of Self-emulsifying Drug Delivery System (SEDDS) of Cepharanthine
The aim of this article was to design a self-emulsifying drug delivery system (SEDDS) of loaded cepharanthine (CEP) to improve the oral bioavailability in rats. Based on the solubility determination and pseudo-ternary phase diagram, isopropyl palmitate (IPP) was chosen as the oil phase. Meanwhile,…
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Pullulan film incorporated with nanocapsules improves pomegranate seed oil anti-inflammatory and…
This study aimed to prepare pullulan films containing pomegranate seeds oil (PSO) based nanocapsules, and evaluate the formulation efficacy in the treatment of atopic dermatitis (AD)-like lesions induced by 2,4-dinitrochlorobenzene (DNCB). The Eudragit RS 100® nanocapsules (PSONC) were prepared by…
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Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation…
Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles…
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Self-assembled tacrolimus-loaded lecithin-chitosan hybrid nanoparticles for in vivo management of…
Lecithin-chitosan hybrid nanoparticles are emerging as a promising nanocarrier for topical drug delivery. They could achieve a maximized encapsulation of hydrophobic drugs due to the lipophilic nature of lecithin that comprises the core while enhancing retention in the upper skin layers using the…
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Encapsulating cannabinoids in lipid-based nanoparticles: THC vs. CBD – Part 2 of the series
Enhancing cannabinoids’ therapeutic efficacy
In our previous technical note, we reported on the encapsulation of CBD vs CBDA (1). The work here-in continues on that theme in terms of studying the differences in encapsulating different cannabinoids into the same lipid-based drug delivery system that…
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Spray (micro) encapsulation of sensitive substances in matrix form: An overview of essential oil and…
Phytochemicals are increasingly found in many food, chemical and agricultural items. Product and process optimization is becoming ever-more important in all of these industries, with a focus on quality, manufacturing efficiency, stability and formulation costs. Essential oils are volatile substances…
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