Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Effect of Material Properties and Variability of Mannitol on Tablet Formulation Development
Abstract
Purpose
Using a high level of mannitol as a diluent in oral formulations can potentially result in tablet defects (e.g., chipping, cracking) during compression. This work aims to scrutinize the linkage between the mechanical properties and material attributes of mannitol and also uncover…
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Orthogonal Gelations to Synthesize Core–Shell Hydrogels Loaded with Nanoemulsion-Templated Drug…
Hydrophobic active pharmaceutical ingredients (APIs) are ubiquitous in the drug development pipeline, but their poor bioavailability often prevents their translation into drug products. Industrial processes to formulate hydrophobic APIs are expensive, difficult to optimize, and not flexible enough…
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Hydrogenated phospholipid, a promising excipient in amorphous solid dispersions of fenofibrate for…
Amorphous solid dispersions (ASD) represent a viable formulation strategy to improve dissolution and bioavailability of poorly soluble drugs. Our study aimed to evaluate the feasibility and potential role of hydrogenated phospholipid (HPL) as a matrix material and solubilizing additive for binary…
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Tailoring the release of drugs having different water solubility by hybrid polymer-lipid…
The aim of this study is to investigate the potential of hybrid polymer-lipid microparticles with a biphasic structure (b-MPs) as drug delivery system. Hybrid b-MPs of Compritol®888 ATO as main lipid constituent of the shell and polyethylene glycol 400 as core material were produced by an innovative…
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MicroCoat™: A Breakthrough in Oral Multiparticulate Formulation Development
Oral multiparticulate systems are often the ‘go to’ solution for flexible dosing, especially in cases where a degree of functionality, such as taste masking or modified release, is required from the formulation. One of the preferred methods of adding functionality to multiparticulates is by fluid…
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Lipid-based formulations: A promising approach for poorly soluble drug delivery via the intestinal…
Abstract
Lipid-based formulation (LBF) has attracted more and more attention as it can significantly improve the efficiency of oral delivery of poorly soluble drugs by exploiting the specific absorption pathway of lipids in the intestinal lymphatic system. Based on the structure and function of…
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Design and Evaluation of Hydrophobic Ion Paired Insulin Loaded Self Micro-Emulsifying Drug Delivery…
Despite several novel and innovative approaches, clinical translation of oral insulin delivery into commercially viable treatment is still challenging due to its poor absorption and rapid degradation in GIT. Thus, an insulin-SDS hydrophobic ion pair loaded self-microemulsifying drug delivery system…
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Development of a time-dependent oral colon delivery system of anaerobic Odoribacter splanchnicus for…
Odoribacter (O.) splanchnicus is an anaerobic member of the human intestinal microbiota. Its decrease in abundance has been associated with inflammatory bowel disease (IBD), non-alcoholic fatty liver, and cystic fibrosis. Considering the anti-inflammatory properties of O. splanchnicus and its…
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Putting children first: Understanding caregivers’ and children’s perspectives on the usability of…
A multi-national online survey was developed to obtain feedback on users’ experiences of administration devices for oral and inhaled paediatric medicines. The questionnaire was divided into two identical parts: 1) for caregivers looking after children aged 0–18 years, and 2) for children aged 10 …
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Oral Solids – Practical Pharmaceutics Part 2
An International Guideline for the Preparation, Care and Use of Medicinal Products
See the new book, edited by Paul Le Brun, Sylvie Crauste-Manciet, Irene Krämer, Julian Smith, Herman Woerdenbag:
Description: Practical Pharmaceutics contains essential knowledge on the preparation, quality…
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