Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Strategies for enhancing the oral bioavailability of cannabinoids
Introduction
Oral administration of cannabinoids is a convenient route of administration in many cases. To enhance the poor and variable bioavailability of cannabinoids, selected strategies utilizing proper delivery systems have been designed. Low solubility in the GI aqueous media is the first…
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Lipids for solid dosage forms
YOUR FORMULATION CHALLENGE - IOI Oleo SOLUTIONS
According to the Biopharmaceutical Classification System (BCS), more than 70% of the APIs used in pharmaceutical preparations are difficult to formulate due to poor solubility and/or permeabilities, and the majority of drug candidates have…
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Risk Assessment and QbD-Based Optimization of Sorafenib Tosylate Colon Targeted Bilayer Tablet: In…
The employment of site-specific administration in colon is a promising technique to improve efficacy and reduce systemic side effects of anticancer medications used in colorectal cancer. However, the physiology of the gastrointestinal tract and colonic environment limit the efficient delivery of…
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A Oral Fast Dissolving Films Containing Lyophilized Labetalol HCL with Hydroxy Propyl…
Introduction: Labetalol HCL is an antihypertensive drug used to treat high blood pressure in the long term management of angina. Labetalol HCL is readily absorbed after oral administration. Labetalol HCl undergoes considerable hepatic first-pass metabolism due to its lipid-soluble nature.…
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Milk Oral Lyophilizates with Loratadine: Screening for New Excipients for Pediatric Use
The development of suitable formulations for the pediatric population remains a challenging field with great advances reported every year in terms of excipients and technology. When developing pediatric formulations, the acceptability of medicines represents a key element to consider. For this…
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A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions:…
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in recent years, with the potential to improve the apparent solubility and, hence, the oral bioavailability of poorly soluble drugs. The process of formulating ASDs is commonly faced with challenges owing to the…
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Long-term daily oral administration of intestinal permeation enhancers is safe and effective in mice
Although protein drugs are powerful biologic therapeutics, they cannot be delivered orally because their large size and hydrophilicity limit their absorption across the intestinal epithelium. One potential solution is the incorporation of permeation enhancers into oral protein formulations; however,…
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Cosolvent and Complexation Systems
Cosolvent and polyethylene glycol (PEG)-based solubilization techniques for the delivery of poorly soluble drugs are discussed in this chapter. The properties of excipients and the physicochemical principles are presented for formulating each type of the solubilized formulations. Cosolvents are…
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Development of Dapagliflozin Solid Lipid Nanoparticles as a Novel Carrier for Oral Delivery:…
Controlling hyperglycemia and avoiding glucose reabsorption are significant goals in type 2 diabetes treatments. Among the numerous modes of medication administration, the oral route is the most common. Introduction: Dapagliflozin is an oral hypoglycemic agent and a powerful, competitive,…
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A Critical Overview of the Biological Effects of Excipients (Part II): Scientific Considerations and…
It is now recognized that a number of excipients previously considered to be “inert” have the capacity to alter drug oral bioavailability through a range of in vivo effects. The various mechanisms through which an excipient can affect in vivo gastrointestinal physiology and drug absorption…
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