Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Prediction of Solid-State Form of SLS 3D Printed Medicines Using NIR and Raman Spectroscopy
Selective laser sintering (SLS) 3D printing is capable of revolutionising pharmaceutical manufacturing, by producing amorphous solid dispersions in a one-step manufacturing process. Here, 3D-printed formulations loaded with a model BCS class II drug (20% w/w itraconazole) and three grades of…
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Development and evaluation of extended release metformin pellets suspended in teneligliptin jelly…
During chronic treatment of diabetes mellitus, a few patients may need combination therapy with metformin hydrochloride (MH). Such combinations are available in the form of tablets. However, the size of these tablets is large and may lead to difficulty in swallowing, especially in case of geriatric…
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The Molded Tablet, a disintegrant-free orally disintegrating tablet, resists thickening…
In clinical practice, a thickening solution is frequently coadministered with medicinal tablets to facilitate swallowing by older patients. This study investigated the effect of thickening solutions on the reduction in drug dissolution from orally disintegrating tablets (ODTs) by testing a…
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Bilayer Buccal Tablets of Furosemide: Design and Evaluation
Aim: In the present study, mucoadhesive bilayer buccal tablets of furosemide were fabricated with the objective of avoiding first-pass metabolism and enhancing the bioavailability along with reducing the dosing frequency.
Methodology: Direct compression method was used to prepare bilayer buccal…
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Influence of spray-drying process on properties of chitosan/xanthan gum polyelectrolyte complexes as…
Polyelectrolyte complexes (PECs) are attractive carriers with recognized potential to enhance oral delivery of poorly soluble high-dosed low-molecular-weight drugs. The formulation of solid oral dosage forms requires the drying of PECs, which may affect their physicochemical and biopharmaceutical…
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Volumetric 3D printing for rapid production of medicines
3D printing (3DP), or additive manufacturing, has been actively investigated as one of the enabling technologies for the impending era of personalized medicines. However, existing 3DP technologies do not afford the speeds required for on-demand production of medicines in fast-paced clinical…
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System model driven selection of robust tablet manufacturing processes based on drug loading and…
Mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be mapped out using in-silico experiments. A system model of a pharmaceutical tablet manufacturing process comparing dry granulation with…
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Design and optimization of pH-sensitive Eudragit nanoparticles for improved oral delivery of…
Design of Experiments (DoE) techniques were used to identify and optimize the parameters involved in the formulation of triclabendazole pH-sensitive Eudragit® nanoparticles (NPs). Using a Placket Burmann design, Eudragit® E, Eudragit® RS, and two stabilizers (PVP and PVA) were evaluated for NPs…
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Is Oral Lipid-Based Delivery for Drug Targeting to the Brain Feasible?
This review outlines the feasibility of oral lipid-based targeted delivery of drugs to the brain, including permeation of the central nervous system’s (CNS) protective blood-brain barrier (BBB). The structure of the BBB and disruption caused by varying disease states highlights the need for…
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Formulating for the Future: Oral Drug Delivery for Improving Bioavailability & Patient Outcomes
Oral drug administration is critical for the delivery of drugs in various therapeutic areas, such as cardiovascular and pain management. It is considered the preferred route of administration due to its significant advantages, including being both painless and convenient. The importance of oral drug…
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