Oral Excipients

Introduction Formulators often face compactability issues for the preparation of orally disintegrating tablets (ODTs) where active pharmaceutical ingredients (APIs) are poorly compressible or formed in a coated pellet. HiSORAD™, one of the best-in-class co-processed excipient for ODT, may work as…
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Wet granulation process is a major unit operation in production of pharmaceuticals as solid dosage oral formulation. Indeed, granulation is used to improve the formulation properties such as flowability, compressibility, and so on for pharmaceutical manufacturing. Different types of granulations can…
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Food-mediated changes to drug absorption, termed the food effect, are hard to predict and can have significant implications for the safety and efficacy of oral drug products in patients. Mimicking the prandial states of the human gastrointestinal tract in preclinical studies is challenging, poorly…
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Objective The understanding of acceptability of existing dosage forms is limited in most of the world and hinders the development of acceptable, age‐appropriate medicines. The attributes of paediatric medicine acceptability may differ from country to country based on culture, healthcare…
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The aim of the current study is to develop and evaluate patient friendly taste masked anthelmintics chewable tablets for pediatrics and geriatrics use. However, the chewable tablets have to disintegrate in the mouth before swallowing, which makes the chewable tablet dosage forms inappropriate for…
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This is the first report on the inclusion of nanocrystals (NCs) within 3D-printed oral solid dosage forms – 3D-printed tablets or printlets – produced by the Melting Solidification Printing Process (MESO-PP) 3D printing technique. This method allowed the incorporation of albendazole (ABZ)…
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galenIQ™ is a sweet-tasting water soluble filler binder derived from sugar beet. It is available in several different morphological forms which are suitable for the formulation and manufacture of oral solid dosage forms including tablets, effervescents, medicated lozenges and powder blends for…
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The number of lipophilic drug candidates in pharmaceutical discovery pipelines has increased in recent years. These drugs often possess physicochemical properties that result in poor oral bioavailability, and their clinical potential may be limited without adequate formulation strategies.…
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There is much interest in converting poorly water-soluble drugs into nanocrystals as they provide extremely high surface area that increases dissolution rate and oral bioavailability. However, nanocrystals are prepared as aqueous suspensions, and once the suspensions are dried for development of…
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The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern1. For more than five decades, the search for new antibiotics has relied heavily on the chemical modification of natural products (semisynthesis), a method ill-equipped to…
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