Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Lamination of pharmaceutical tablets: classification and influence of process parameters
Lamination is a common industrial problem during the production of pharmaceutical tablets. It corresponds to a failure of the tablet in one or several planes parallel to the surface and passing through the tablet band. But different kinds of lamination exist, and a classification of the different…
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Development of Self-Microemulsifying Drug Delivery System to Improve Nisoldipine Bioavailability:…
The authors attempted to fabricate a novel lipid-based formulation of a lipophilic drug, nisoldipine (NISO). As NISO belongs to BCS class 2 drug, it suffers from low bioavailability (5%). Hence, the research was intended to ameliorate oral bioavailability of NISO via intestinal lymphatic transport.…
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Therapeutic efficacy and gastrointestinal biodistribution of polycationic nanoparticles for oral…
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world and is the second leading cause of cancer related deaths. New cases are increasingly diagnosed every day, but current therapeutic options are still insufficient for an effective treatment. In CRC treatment, there is a…
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Lymphatic transport system to circumvent hepatic metabolism for oral delivery of lipid-based…
The oral route of administration for lipid-based nanocarriers is of immense importance for the drugs having low bioavailability because of extensive first-pass metabolism. These drug delivery systems have reportedly improved oral bioavailability via lymphatic transport. The solubility issues of a…
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Oral colon delivery platform based on a novel combination approach: Design concept and preliminary…
An oral colon delivery platform based on a novel combination strategy, leveraging multiple physiological characteristics of the intestine, is proposed. The system comprises a drug core, a water-swellable/soluble inner layer based on a hydrophilic cellulose derivative and an enteric outer layer…
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Interspecies differences in gastrointestinal physiology affecting the in vivo performance of oral…
Various physiological factors in the gastrointestinal (GI) tract affect the in vivo performance of orally administered dosage forms. In this review article, we summarize the formulation-related interspecies differences (particularly under the fasted state) between humans and laboratory animals.…
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Enteric-coated bacteriophage tablets for oral administration against gastrointestinal infections
Intestinal Pseudomonas aeruginosa is highly problematic in immunocompromised patients such as those in intensive care units in hospitals. Phage therapy is an attractive alternative or supplementary therapy to antibiotics as it not only kills multidrug-resistant bacteria, but also minimises the…
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UNGAP best practice for improving solubility data quality of orally administered drugs
An important goal of the European Cooperation in Science and Technology (COST) Action UNGAP (UNderstanding Gastrointestinal Absorption-related Processes, www.ungap.eu) is to improve standardization of methods relating to the study of oral drug absorption. Solubility is a general term that refers to…
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Formulation and Evaluation of Baclofen-Meloxicam Orally Disintegrating Tablets (ODTs) Using…
Purpose: This study aimed to formulate an orally disintegrating tablet (ODT) containing both baclofen and meloxicam together for treating osteoarthritis.
Methods: Direct compression method was used to prepare ODTs using three types of co-processed excipients (Prosolv ODT G2®, F-melt®, and…
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Pharmaceutical oils for Cannabinoid drug products from ADM-SIO
Medicinal Cannabinoids
There are currently more than 150 cannabinoid-based products under development in the world. The first US FDA approved product Epidiolex®, isolated from the cannabis plant and indicated for severe forms of epilepsy is formulated with Sesame oil. Other approved products like…
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