Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Application of commercially available mesoporous silica for drug dissolution enhancement in oral…
Due to the high number of poorly water-soluble active pharmaceutical ingredients, oral drug delivery development has become challenging. One of the strategies to enhance drug solubility and to achieve high oral bioavailability is to formulate such compounds into amorphous solid dispersions. In…
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Chitosan-encapsulated niosomes for enhanced oral delivery of atorvastatin
Atorvastatin is the most commonly used hypolipidemic drug. It provides excellent protection against cardiovascular disease especially in subjects having high risk factors. However, atorvastatin has problematic biopharmaceutical characteristics due to low dissolution rate and extensive pre-systemic…
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Sensing technologies and experimental platforms for the characterization of advanced oral drug…
Complex and miniaturized oral drug delivery systems are being developed rapidly for targeted, controlled drug release and improved bioavailability. Standard analytical techniques are widely used to characterize i) drug carrier and active pharmaceutical ingredients before loading into a delivery…
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Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin
Vancomycin (Van) is a key antibiotic of choice for the treatment of systemic methicillin resistant Staphylococcus aureus (MRSA) infections. However, due to its poor membrane permeability, it is administered parenterally, adding to the cost and effort of treatment. The poor oral bioavailability of…
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3D Printing: an appealing technology for the manufacturing of solid oral dosage forms
Objectives
The traditional manufacturing methods of solid oral dosage forms (SODFs) are reported to be time-consuming, highly expensive and not tailored to the patient’s needs. Three-dimensional printing (3DP) is an innovative emerging technology that can help to overcome these issues. The aim of…
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Enhanced oral bioavailability of rutin by a self-emulsifying drug delivery system of an extract of…
The aim of this study was to develop and optimize a self-emulsifying drug delivery system (SEDDS) containing an extract of calyces from Physalis peruviana with high mucus permeating properties to increase the bioavailability and the hypoglycemic activity of the active metabolites of the extract. The…
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Accuracy of Dose Administered to Children Using Off-Labelled or Unlicensed Oral Dosage Forms
The pediatric population suffers from a lack of age-appropriate medicines leading to unsafe situations when off-labelled or unlicensed drugs are used. Assessing the best option to administrate medicines when manipulations are required is essential in order to improve child care. This study aimed to…
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An in vitro approach to study the absorption of a new oral formulation of berberine
Background
Berberine (BBR) possesses several biological activities in humans, but the poor water solubility and low oral bioavailability preclude its pharmacological use. To overcome these limitations, several formulations have been prepared including encapsulation, micro- and nano-emulsion. The…
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N-trimethyl chitosan coated nano-complexes enhance the oral bioavailability and chemotherapeutic…
N-trimethyl chitosan (TMC) is a multifunctional polymer that can be used in various nanoparticle forms in the pharmaceutical, nutraceutical and biomedical fields. In this study, TMC was used as a mucoadhesive adjuvant to enhance the oral bioavailability and hence antitumor effects of gemcitabine…
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Statistical design of experiment-based formulation development and optimization of 3D printed oral…
Purpose
Producing several controlled- release 3D printed tablets from polymer blends with the required target product profile has been a challenge. Thus, experimental design could be applied to rationally explore the impact of the formulation excipients on drug release.
Methods
The optimization…
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