Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Modification of microenvironmental pH of nanoparticles for enhanced solubility and oral…
This study aimed to develop a novel pH-modified nanoparticle with improved solubility and oral bioavailability of poorly water-soluble celecoxib by modifying the microenvironmental pH. After assessing the impact of hydrophilic polymers, surfactants and alkaline pH modifiers on the drug solubility,…
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New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline…
Abstract
Nanocrystalline cellulose (CNC) has emerged as a subject of researcher’s interest because of its diverse attributes encompassing biocompatibility, sustainability, a high aspect ratio, and an abundance of −OH groups suitable for modifications. Sugarcane bagasse microcrystalline cellulose…
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Dissolution and antioxidant potential of apigenin self nanoemulsifying drug delivery system (SNEDDS)…
Abstract
Self-nanoemulsifying drug delivery systems (SNEDDS) have been used to improve the oral bioavailability of various drugs. In the current study, apigenin was developed as SNEDDS to solve its dissolution problem and enhance oral bioavailability and antioxidant potential. SNEDDS were…
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Closer to the Formulator (C2F) – A Center of Excellence by DFE Pharma
DFE Pharma is a global leader in pharma and nutraceutical excipient solutions. They develop, produce and supply high quality functional excipients for use in the pharmaceutical, biopharmaceutical, and nutraceutical industries for respiratory, oral solid dose (OSD), ophthalmic and parenteral…
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Polymeric Amorphous Solid Dispersions of Dasatinib: Formulation and Ecotoxicological Assessment
Abstract
Dasatinib (DAS), a potent anticancer drug, has been subjected to formulation enhancements due to challenges such as significant first-pass metabolism, poor absorption, and limited oral bioavailability. To improve its release profile, DAS was embedded in a matrix of the hydrophilic polymer…
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Transdermal Delivery of Pramipexole Using Microneedle Technology for the Potential Treatment of…
Parkinson’s disease (PD) is a debilitating neurodegenerative disease primarily impacting neurons responsible for dopamine production within the brain. Pramipexole (PRA) is a dopamine agonist that is currently available in tablet form. However, individuals with PD commonly encounter difficulties with…
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Solid self-emulsifying casein carrier for the improvement on the oral bioavailability of simvastatin
Simvastatin (SV) is a statin drug that can effectively control cholesterol and prevent cardiovascular diseases. However, SV is water-insoluble, and poor oral bioavailability (<5 %). Solid self-emulsifying carrier system is more stable than liquid emulsions, facilitating to improve the solubility…
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The dawning era of oral thin films for nutraceutical delivery: From laboratory to clinic
Abstract
Oral thin films (OTFs) are innovative dosage forms that have gained tremendous attention for the delivery of nutraceuticals. They are ultra-thin, flexible sheets that can be easily placed on the tongue, sublingual or buccal mucosa (inner lining of the cheek). These thin films possess…
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Amorphous – state Characterization and Dissolution Behaviour of Efavirenz – Tocopheryl…
ABSTRACT
The aim of the present investigation was to enhance the aqueous solubility and dissolution rate of a poorly soluble drug, efavirenz, by preparation of solid dispersions with tocopheryl polyethylene glycol succinate (TPGS)-1000, a non-ionic surfactant. Phase solubility studies suggested…
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Engineering of Highly Drug Loaded, Free-Flowing Mini-Particles via Tangential Spray Fluid Bed…
This poster was presented at the PBP World Meeting 2024 by Glatt Pharmaceutical Services with the Utrecht Institute for Pharmaceutical Sciences:
Introduction
Personalized medicine combines various approaches to establish therapy regimens that are tailored to individual patients. In oral drug…
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