Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Formulation and Characterization of Eplerenone Mucoadhesive Buccal Tablets
Mucoadhesive drug release system is a preferably unidirectional release system where mucosal epithelial exterior is enclosed by the mucus deposit that interacts with the bio-adhesive drug delivery system and swelling time of the buccal dosage form which is amplified by mucin molecules at the…
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Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for…
P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor intestinal permeation and limited bioavailability following oral administration. P-gp inhibitors, including small molecule drugs, natural constituents, and…
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Pharmacotechnical and Analytical Preformulation Studies for Cannabidiol Orodispersible Tablets
Obtaining orodispersible tablets (ODT) containing substances from the 2nd Biopharmaceutical Class has raised concerns as the dissolution test is challenging. This study aimed to select suitable excipients for developing orodispersible tablets containing cannabidiol (CBD) by direct compression…
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Potential pharmacokinetic interaction between orally administered drug and osmotically active…
Poorly absorbable sugar alcohols (e.g., mannitol, sorbitol, and maltitol) are the excipients frequently contained in pediatric dosage forms. Due to their osmotically active properties, certain amount of sugar alcohols reportedly reduces oral bioavailability of concomitant drugs. This fact implies…
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Self-assembled micelles enhance the oral delivery of curcumin for the management of alcohol-induced…
Curcumin (CUR) shows great potential in the management of alcohol-use disorders. However, the hydrophobicity and poor oral bioavailability result in the limited therapeutic efficacy of CUR against alcohol-induced tissue injury. Here, self-assembled Soluplus® micelles (Ms) were developed for the…
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Development of a BCS Class II Drug Microemulsion for Oral Delivery: Design, Optimization, and…
Our work is aimed at exploring the composition and the properties of microemulsion (ME), as a drug delivery system, to enhance the permeability across the gastrointestinal (GI) barrier of fenofibrate, a BCS class II drug. It is a prodrug that is converted rapidly after oral administration into a…
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Self-emulsifying formulations to augment therapeutic efficacy of nutraceuticals: From concepts to…
Background
Nutraceuticals often referred as medicinally or nutritionally functional foods has drawn extensive attention in recent years because of their wide array of pharmacological activities. It has been well established that the consumption of nutraceuticals is consistently linked with…
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Structured edible lipid-based particle systems for oral drug-delivery
Oral administration is the most popular and patient-compliant route for drug delivery, though it raises great challenges due to the involvement of the gastro-intestine (GI) system and the drug bioavailability. Drug bioavailability is directly related to its ability to dissolve, transport and/or…
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Fabrication and Characterization of Fast-Dissolving Films Containing Escitalopram/Quetiapine for the…
Major depressive disorder (MMD) is a leading cause of disability worldwide. Approximately one-third of patients with MDD fail to achieve response or remission leading to treatment-resistant depression (TRD). One of the psychopharmacological strategies to overcome TRD is using a combination of an…
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Three-dimensional printing of tablets – a potential approach to on-clinical-site extemporaneous…
The oral route is the most common form of drug administration, being a safe and convenient, particularly for solid oral dosage forms. Current large-scale manufacturing techniques mostly result in fixed dose units and allow a limited choice of dosage strengths. In some cases, there is a need for…
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