Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Investigation of hydroxypropyl-β-cyclodextrin inclusion complexation of two poorly soluble model…
The goal for any formulation design of poorly soluble drugs is to increase the solubility. However, increased solubility is a challenge when the drug is administered to the oral cavity as rapidly dispersing or mucoadhesive buccal films. Most drugs are bitter and increased solubility may correlate…
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Lipid-based formulations: A winning strategy for oral bioavailability enhancement
The key to lipid-based formulation success relies in the right selection of the lipid excipients to develop an optimized formulation, enabling solubilization of the drug throughout the digestion process for enhancement of oral bioavailability.
If you are not familiar with lipid-based formulation,…
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Molecular Dynamics Simulations Reveal Membrane Interactions for Poorly Water-Soluble Drugs: Impact…
Molecular transport mechanisms of poorly soluble hydrophobic drug compounds to lipid membranes were investigated using molecular dynamics (MD) simulations. The model compound danazol was used to investigate the mechanism(s) by which bile micelles delivered it to the membrane.
The interactions…
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Raman monitoring of semi-continuously manufactured orodispersible films for individualized dosing
Orodispersible films are promising oral dosage forms for special populations. To enable continuous manufacturing of orodispersible films, monitoring of the active pharmaceutical ingredient contained in the final product is essential. However, there are few methods to confirm the target contents in…
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Comparing Different Moisture Protective Instant Release Coatings for Solid Oral Dosage Forms
Introduction: Drug stability and shelf life are main targets of current pharmaceutical development as many active ingredients are highly moisture sensitive. Instead of using impermeable and expensive packaging materials it appears advisable to test moisture protective instant release film coatings.…
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The Influence of Solidification on the in vitro Solubilisation of Blonanserin Loaded Supersaturated…
Supersaturated silica-lipid hybrids have previously demonstrated improved in vitro solubilisation and in vivo oral bioavailability of poorly water-soluble drugs, however were only fabricated using a single lipid (LFCS type I formulations) and were not compared to their liquid precursors. This study…
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Effect of Carrier Type and Tween® 80 Concentration on the Silymarin Release from the Solid…
The following poster was presented first at AAPS PharmSci 360 in October 2020. We had the chance to get a short introduction from the creator Valentyn Mohylyuk as a audio file.
PURPOSE
Silybin (the active component of Silymarin) is a weak acid (pKa 5.7) having low solubility in gastric…
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An investigation into applicability of different compression behaviour assessment approaches for…
Increasing expectations to understand material properties and process parameters impact on drug product performance resulted in increased efforts towards evaluation of drug/excipients mixtures, particularly during compression. Several research groups introduced material classification methodologies…
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Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications
Purpose: A multitude of different versions of the same medication with different inactive ingredients are currently available. It has not been quantified how this has evolved historically. Furthermore, it is unknown whether healthcare professionals consider the inactive ingredient portion when…
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Bioavailability Improvement of Carbamazepine via Oral Administration of Modified-Release Amorphous…
The purpose of this study was to improve the bioavailability of carbamazepine (CBZ), a poorly water-soluble antiepileptic drug, via modified-release amorphous solid dispersions (mr-ASD) by a thin film freezing (TFF) process. Three types of CBZ-mr-ASD with immediate-, delayed-, and controlled-release…
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