Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
How can oral paediatric formulations be improved? A challenge for the XXI century
Paediatric oral formulations need to be improved. This is an indisputable fact that has gain attention from the regulators, the medical staff, and researchers. The lack of adequate medicines developed for children, resulted in several off-label and unlicensed prescriptions, increasing the risks of…
Read More...
Read More...
Mechanical Characteristics of Orally Disintegrating Films: Comparison of Folding Endurance and…
The tensile test is the most widely used method for testing the mechanical characteristics of orally disintegrating films (ODFs). The other available test is the folding endurance (FE) test, which is more suitable for clarifying the actual strength during the manufacturing and dosing. However, the…
Read More...
Read More...
Evaluation of Lactose-Based Direct Tableting Agents’ Compressibility Behavior Using a Compaction…
A compaction simulator (CS) is a single-punch instrument that records data during the powder compaction process. The aim of the study was to determine the behavior of lactose-based direct tableting agents (DTAs) by CS. The data recorded were used to evaluate the flowability and compressibility of…
Read More...
Read More...
Enhanced Loading Efficiency and Mucoadhesion Properties of Gellan Gum Thin Films by Complexation…
Polymeric oral thin films (OTFs) were prepared by the casting method, combining gellan gum (GG), a water-soluble polysaccharide, and glycerol (Gly) as a plasticizing agent. GG-Gly films were investigated as potential systems for buccal drug delivery using fluconazole (Class I of the…
Read More...
Read More...
Fused deposition modeling of API-loaded mesoporous magnesium carbonate
In this thesis, the incorporation of drug loaded mesoporous magnesium carbonate as an excipient for the additive manufacturing of oral tablets by fused deposition modeling was investigated. Cinnarizine, a BCS class II drug, was loaded into the pores of the mesoporous material via a soaking method,…
Read More...
Read More...
Development and Evaluation of Astaxanthin Orally Disintegrating Tablets Prepared from Coprocessed…
The world’s population is aging; therefore, conventional pharmaceutical dosage forms designed for adult are not suitable. Orally disintegrating tablets (ODTs) are innovative dosage forms designed to overcome the problem of difficulty in swallowing or dysphagia, which is a common problem among all…
Read More...
Read More...
Comparison of Different Liquid and Semisolid Vehicles Selected for Oral Administration of Pellets…
The acceptability and palatability of a dosage form are extremely important to improve patient compliance. Mixing oral solid dosage forms with food carriers is often necessary to ease swallowing and provide the taste-masking effect. The present research investigated how a liquid or semisolid carrier…
Read More...
Read More...
Characterization and modeling of the viscoelasticity of pharmaceutical tablets
Evolution of the compaction properties of powders with the compaction speed (strain rate sensitivity, SRS) is a common phenomenon during the manufacturing of pharmaceutical tablets. Nevertheless, several different phenomena can be responsible of the SRS like friction, viscoelasticity,…
Read More...
Read More...
Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of…
Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase. In recent years, it has been shown that tolcapone is a potent inhibitor of…
Read More...
Read More...
Optimized flurbiprofen sustained-release matrix pellets prepared by extrusion/spheronization
Flurbiprofen (FBP) is an ibuprofen derivative with less gastric side effects and short biological half-life (4.7–5.7 h). The study aimed to formulate FBP as a sustained-release pellets by extrusion/spheronization to overcome its short half-life and to decrease dose frequency. The wet mass of the…
Read More...
Read More...