Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Optimized flurbiprofen sustained-release matrix pellets prepared by extrusion/spheronization
Flurbiprofen (FBP) is an ibuprofen derivative with less gastric side effects and short biological half-life (4.7–5.7 h). The study aimed to formulate FBP as a sustained-release pellets by extrusion/spheronization to overcome its short half-life and to decrease dose frequency. The wet mass of the…
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Compaction and tableting properties of composite particles of microcrystalline cellulose and…
Excipients with improved functionality have continued to be developed by the particle engineering strategy of co-processing. The aim of this study was to evaluate the compaction and tableting properties of composite particles of microcrystalline cellulose (MCC) and crospovidone (CPV) engineered by…
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Biopharmaceutical implications of excipient variability on drug dissolution from immediate release…
Elucidating the impact of excipient variability on oral product performance in a biopharmaceutical perspective would be beneficial and allow excipient implementation on Quality by Design (QbD) approaches. The current study investigated the impact of varying viscosity of binders (hypromellose (HPMC))…
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Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules
Oral ingestion remains as the most convenient route of administration for the application of pharmaceuticals since it is non-invasive and does not require trained personnel to administer the drugs. Despite significant progress in novel oral drug delivery platforms over the past few decades, the oral…
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Taste Masking of Pharmaceutical Formulations: Review on Technologies, Recent Trends and Patents
The majority of active pharmaceutical ingredients (APIs) found in oral dosage forms have unpleasant or obnoxious taste. Taste is one of the important parameters which governs patient compliance and also decides the success of a product in the market. Undesirable taste or the bitter taste is a major…
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In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it dicult to achieve therapeutic levels…
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The influence of porosity on tablet subdivision
A tablet microstructure, especially the porosity, is a crucial parameter that influences the mechanical properties. Herein, tablet subdivisions were studied as a function of tablet porosity. The tablets were manufactured in the presence of different diluents, namely microcrystalline cellulose,…
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Improved oral bioavailability and target delivery of 6-Shogaol via Vitamin E TPGS-modified…
6-Shogaol is one component of ginger, which has been described to possess various health-promoting effects including anticancer, anti-inflammatory, antioxidant and antiatherogenic. However, poor water solubility has limited the aforementioned health benefits and clinical applications of the drug.…
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Regulating the pH of bicarbonate solutions without purging gases: Application to dissolution testing…
Dissolution media based on bicarbonate buffers closely mimic the environment of intestinal fluids and thus improve in vitro in vivo correlation compared to phosphate buffers. Purging gases into the medium is used as a method to stabilise bicarbonate buffers; however, this causes issues due to the…
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Nanostructured lipid carriers as oral delivery systems for improving oral bioavailability of…
The aim of this study was to fabricate nanostructured lipid carriers, NLCs, of nintedanib (BIBF) to improve its oral bioavailability. Two types of NLCs loaded with BIBF (BIBF-NLCs-1 and BIBF-NLCs-2) were prepared by the melt-emulsification technique. BIBF-NLCs-1 and BIBF-NLCs-2 showed nanoscale…
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