Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Oral delivery of non-viral nucleic acid-based therapeutics – do we have the guts for this?
Gene therapy with RNA and pDNA-based drugs is limited by poor enzymatic stability and poor cellular permeation. The delivery of nucleic acids, in particular by the oral route, remains a major hurdle. This review will focus on the barriers to the oral delivery of nucleic acids and the strategies, in…
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Oral Bioavailability Enhancement and Anti-Fatigue Assessment of the Andrographolide Loaded Solid…
Andrographolide (AG), a major diterpene lactone isolated from Andrographis paniculata (Burm. f.) Nees (Acanthaceae), possesses a wide spectrum of biological activities. However, its poor water solubility and low bioavailability limit its clinical application.
Therefore, this study aimed to…
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Physical modification of Thai rice starch and its application as orodispersible film former
The objective of this study was to investigate the application of the physically modified rice starch (MRS) produced by alcoholic-alkaline (MRS-AA) and planetary ball-milling (MRS-BM) methods as an ODF film former. Rice starch was isolated from Thai rice grain. XRD and ATR-FTIR results confirmed…
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Oral Drug Delivery: Oral Delivery of Biologics for Precision Medicine
The emerging field of precision medicine is rapidly growing, fostered by the advances in genome mapping and molecular diagnosis. In general, the translation of these advances into precision treatments relies on the use of biological macromolecules, whose structure offers a high specificity and…
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New Delivery Method Could Make Niclosamide an Effective Antiviral to Treat COVID-19
Repurposing drugs such as the FDA-approved niclosamide is a highly efficient way to leverage drugs with known safety profiles to fight the coronavirus outbreak. College of Pharmacy researchers at The University of Texas at Austin are now using new drug delivery formulation technologies to increase…
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Development and evaluation of TPGS/PVA-based nanosuspension for enhancing dissolution and oral…
In this study, we developed ticagrelor-dispersed nanosuspension (TCG-NSP) to enhance the dissolution and oral bioavailability of ticagrelor (TCG) through a statistical design approach. TCG, a reversible P2Y12 receptor antagonist, is classified as a biopharmaceutics classification system (BCS) class…
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End-to-End Continuous Manufacturing of Conventional Compressed Tablets: From Flow Synthesis to…
An end-to-end continuous pharmaceutical manufacturing process was developed for the production of conventional direct compressed tablets on a proof-of-concept level for the first time. The output reaction mixture of the flow synthesis of acetylsalicylic acid was crystallized continuously in a mixed…
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Solving a sticking related tablet problem by multivariate statistics and computational tomographic…
This work identifies the cause of sticking of granules in an industrial process of tableting. Retrospective multivariate statistical analysis of industrial scale batches' records (PLS, properties and manufacturing conditions of granules and tablets) identified the air flow rate in both granulation…
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Lyophilisation Improves Bioactivity and Stability of Insulin-Loaded Polymeric-Oligonucleotide…
The oral bioavailability of therapeutic proteins is limited by the gastrointestinal barriers. Encapsulation of labile proteins into nanoparticles is a promising strategy. In order to improve the stability of nanoparticles, lyophilisation has been used to remove water molecules from the suspension.…
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Influence of the Punch Speed on the Die Wall/Powder Kinematic Friction During Tableting
Influence of the compaction speed on the final tablet properties is an important challenge during the scale-up of a solid dosage form. This strain rate sensitivity is generally attributed to the time dependent deformation behavior of the powder. In this work, we studied the influence of the speed on…
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