Oral Excipients

The aim of this work was to prepare mucoadhesive buccal films for local release of Lactobacillus brevis CD2, which shows interesting anti-inflammatory properties due to its high levels of arginine deiminase. Hydroxypropylmethylcellulose-based films were prepared by means of a modified casting…
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Excipient-moisture interaction can be a critical attribute in determination of product stability. This study aimed to investigate influence of integrating excipients having different moisture interaction into moisture sensitive drug formulations. Aspirin was formulated with maize starch (MS),…
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One of the major challenges for modern formulation development is the increasing number of poorly water-soluble drugs. A common formulation approach to improve the solubility of those poorly soluble active ingredients is to formulate them as amorphous solid dispersions (ASDs) with a suitable polymer…
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Despite the legislative initiatives by the regulatory European medical agency (EMA) and the United States Food and Drug Administration Authority (FDA), an approved drug with child-appropriate dosage formulations are still absent for many drugs for pediatric heart failure. The pediatric patients are…
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The objective of this study was to develop and evaluate a MUPS formulation intended for treatment digestive tract ulcers.Work involves evaluation of different formulations of esomeprazole magnesium having enteric polymer and plasticizers to understand impact on dissolution. A three-factor,…
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Continuous manufacturing offers significant advantages over conventional batch processing such as smaller equipment, less footprint and no need for upscaling experiments. With these benefits, come challenges as well. In a fully continuous process, the excipients must be added through individual…
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In tablet manufacturing, a lubricant is added in a tumbling mixer prior to compression to ensure that the tablet is ejected smoothly without sticking or breakage. Control and monitoring of this process is critical as process parameters can negatively affect final tablet properties. Inline monitoring…
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Cannabidiol (CBD) and the potential benefit is the current hot topic. Just found this publication by the group of Elka Touítou Hebrew University of Jerusalem from 2003. She will hold at this years PBP Worldmeeting the presentation: "Delivery of cannabinoids to and across the skin". It is interesting…
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Co-processed Excipients: Drug approval process | Compendial vs. Novel Excipients Common Technical Documentation Format – CTD Throughout a drug approval process a team of drug regulatory experts needs to compile mandatory documentation, which comply with the common technical documentation format.…
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Roller compaction is the main technique employed in dry granulation. Ribbon sticking and splitting are among the major factors that can hinder the use of this process for some formulations. Ribbon splitting can occur either transversally (through the ribbon thickness) or longitudinally (through the…
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