Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Olanzapine, improvement of biopharmaceutical performance in solid dosage form
Olanzapine is an effective antipsychotic drug used for the treatment of positive and negative symptoms of schizophrenia.
It suffers from poor water solubility in addition to extensive first-pass metabolism in the liver to inactive metabolites, resulting in a poor oral bioavailability of nearly…
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Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and…
A design of experiments (DOE) approach (2-level full factorial design) was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets comprising starch-based pellets and excipient granules and to optimize and validate the design…
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Continuous twin screw granulation: impact of binder addition method and surfactants on granulation…
Despite the recent commercialization of several drug products manufactured through continuous manufacturing techniques, knowledge on the formulation aspect of these techniques, such as twin screw wet granulation, is still rather limited.
Previous research identified lactose/MCC/HPMC as a robust…
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Oral formulation strategies to improve the bioavailability and mitigate the food effect of…
Abiraterone acetate, marketed as Zytiga®, is an antiandrogen medication used in the treatment of prostate cancer. Abiraterone acetate is a BCS Class IV compound associated with several oral delivery challenges. Its low solubility and high lipophilicity lead to poor oral bioavailability (<10%) and…
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Along the Process Chain to Probiotic Tablets: Evaluation of Mechanical Impacts on Microbial…
Today, probiotics are predominantly used in liquid or semi-solid functionalized foods, showing a rapid loss of cell viability.
Due to the increasing spread of antibiotic resistance, probiotics are promising in pharmaceutical development because of their antimicrobial effects. This increases the…
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Co-processed excipients for direct compression of tablets
Tablets are the most frequently employed dosage form. Their advantage lies in their availability, easy administration, good stability, and low price. The easiest technology to produce tablets is direct compression, even though the use of the method requires overcoming many obstacles, mainly related…
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A model to simultaneously evaluate the compressibility and compactibility of a powder based on the…
The present study aimed to establish a new model to evaluate the compressibility and compactibility of materials simultaneously.
Eighteen types of pharmaceutical excipients were studied via direct compaction. The model was established as CR = y0 + Ae- bP, r2 ≥ 0.9649 (where CR is the compression…
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Continuous twin screw granulation: Influence of process and formulation variables on granule quality…
In recent years, continuous manufacturing techniques, such as twin screw wet granulation, have gained significant momentum.
Due to the large diversity of the (model) formulations and equipment, it is often difficult to generalize conclusions about the importance of process settings. As only…
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Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying
Continuous manufacturing (CM) is a promising strategy to achieve various benefits in the context of quality, flexibility, safety and cost in pharmaceutical production.
One of the main technical challenges of CM is that the process needs to handle transient conditions such as the start-up phase…
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Powder flow and mixing in different tablet press feed frames
Tablets can be manufactured using a rotary tablet press, which consists of a feed frame followed by the compression and compaction of the powder and subsequent ejection of the tablets.
From Quality by Design (QbD) perspectives the feed frame plays a critical role and effects products critical…
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