Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
Carvedilol solid dispersion for enhanced oral bioavailability using rat model
The objective of the present study was to develop a solid dispersion formulation to improve oral bioavailability of poorly water-soluble drug carvedilol. Several solid dispersions were prepared by fusion-solvent method mixing different concentrations of Gelucire 44/14 and Gelucire 50/13. To the…
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Decoding the Small Size Challenges of Mini-tablets for Enhanced Dose Flexibility and Micro-dosing
Mini-tablets are an age appropriate dosage form for oral administration to pediatric and geriatric patients, either as individual mini-tablets or as composite dosage units.
Smaller mini-tablets than the commonly used 2 mm or larger size would offer added advantages to more tailored delivery of…
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Self-Micellizing Technology Improves the Properties of Ezetimibe and Increases Its Effect on…
The aim of this work was to develop ezetimibe self-micellizing solid dispersions using Kolliphor® RH40 (MS-K) as a surfactant incorporating ezetimibe (EZ) into the croscarmellose hydrophilic carrier.
Different ezetimibe:Kolliphor® ratios were studied to select micellar systems that improve the…
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Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies
Viral infections affect three to five million patients annually.
While commonly used antivirals often show limited efficacy and serious adverse effects, herbal extracts have been in use for medicinal purposes since ancient times and are known for their antiviral properties and more tolerable side…
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Self-Emulsifying Drug Delivery Systems: Easy to Prepare Multifunctional Vectors for Efficient Oral…
Self-emulsifying drug delivery systems (SEDDS) have been mainly investigated to enhance the oral bioavailability of drugs belonging to class II of the Biopharmaceutics Classification System. However, in the past few years, they have shown promising outcomes in the oral delivery of various types of…
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Development of dual–release pellets of the non-steroidal anti–inflammatory drug celecoxib
In the current study, once-a-day dual-release pellets of the selective non-steroidal anti-inflammatory drug celecoxib (200 mg) was developed to treat arthritis.
Pellets were prepared where a 100 mg celecoxib, located in the outer layer, was released in an immediate-release (IR) pattern, whereas…
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A Mechanistic Understanding of Compression Damage to the Dissolubility of Coated Pellets in Tablets
Damage to the drug diffusion coat barrier of controlled release pellets by the compaction force when preparing multiple-unit pellet system tablets is a major concern.
Previous studies have shown that pellets located at the tablet axial and radial peripheral surfaces were more susceptible to…
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Relationship between compression pressure, mechanical strenghth and release properties of tablets
Tablets are a complex drug delivery system consisting of the active pharmaceutical ingredients and excipi- ents.
Tablet production involves a series of unit operations in which drugs and excipients are subjected to mechanical stresses, such as compression pressure, thus imposing changes in the…
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Optimization and characterization of novel sustained release supermicro-pellet based dry suspensions…
Traditional dosage forms of dexibuprofen extremely limit their clinical applications because of the bitter taste and the frequent drug administration caused by the relatively short half-life of the drug.
This study aims to design novel sustained release (SR) supermicro-pellet based dry…
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Unique coated neusilin pellets with a more distinct and fast visual detection of nerve agents and…
Pellets with an immobilized enzyme (acetyl- or butyrylcholinesterase) are the up-to-date type of carriers used for the detection of nerve agents (soman, sarin, tabun, VX, Novichok) and other cholinesterase inhibitors such as organophosphate and carbamate insecticides (parathion, malathion).
They…
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