Any excipient that can be taken through the mouth can be labelled as an oral excipient.
Pharma Excipients
Oral Excipients
The Past, Present, and Future of Oral Dosage Forms for Children
Abstract
The administration of medications to children has been a challenge for parents and caregivers for generations. Pharmaceutical companies have often overcome the difficulties of weight-based dosing and the inability of most young children to swallow solid dosage forms by creating oral…
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Dry Granulation in Solid Oral Formulation: Advantages of Spray-Dried Mannitol in Roll Compaction
The Application of Fillers and Binders in Solid Dosage Formulation
Pharmaceutical excipients are frequently used as fillers and fillers/binders in the formulation of solid dosage forms. Fillers add volume and confer mechanical properties that offer greater flowability and compressibility which…
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Surfactants for stabilization of dermal emulsions and their skin compatibility under UVA…
Phospholipids are versatile formulation compounds with high biocompatibility. However, no data on their effect on skin in combination with UVA radiation exist. Thus, it was the aim of this work to (i) develop o/w nanoemulsions (NEs) differing in surfactant type and to investigate their…
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Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for…
The targeting and mucoadhesive features of chitosan (CS)-linked solid lipid nanoparticles (SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a novel and potential oral therapeutic option for ulcerative colitis (UC) treatment. Different FEX-CS-SLNs with varied…
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Application of 3D printing in early phase development of pharmaceutical solid dosage forms
Abstract
Three-dimensional printing (3DP) is an emerging technology, offering the possibility for the development of dose-customized, effective, and safe solid oral dosage forms (SODFs). Although 3DP has great potential, it does come with certain limitations, and the traditional drug manufacturing…
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In situ triggered, floating delivery systems of capsaicin for prolonged gastroprotection
Abstract
Capsaicin (CAP) has been implicated as a gastroprotective agent in the treatment of peptic ulcers. However, its oral administration is hampered by its poor aqueous solubility and caustic effect at high administered doses. To address these limitations, we describe the development of gastric…
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Impact testing as a new approach to determine mechanical strength of pharmaceutical tablets
Abstract
One of the most common standardised testing of tablet strength in the pharmaceutical industry is the tablet breaking force, which records data related to diametrical compression. This method does not account for a rapid transfer of energy such as free-falling tablets hitting a solid…
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Advancing oral drug delivery: The science of fast dissolving tablets (FDTs)
The field of oral drug delivery has witnessed significant advancements, with a focus on developing innovative formulations to address challenges associated with traditional dosage forms, especially for patients with difficulties in swallowing. Fast Dissolving Tablets (FDTs) have emerged as a…
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Cushion-coated pellets for tableting without external excipients
Multiple-unit dosage forms prepared by compacting pellets offer important manufacturing and compliance advantages over pellet-filled capsules. However, compaction may negatively affect the release control mechanism of pellets, and subunits may not be readily available after intake. Application of a…
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Tailoring drug release in bilayer tablets through droplet deposition modeling and injection molding
Abstract
This study explores the innovative production of personalized bilayer tablets, integrating two advanced manufacturing techniques: Droplet Deposition Modeling (DDM) and Injection Molding (IM). Unlike traditional methods limited to customizing dense bilayer medicines, our approach uses…
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