Orally Dissolving Technology Excipient

HiSORAD is a state-of-the-art co-processed excipient for orally disintegrating tablets designed to have well-balanced property between orally disintegration time and tablet hardness. HiSORAD enables to produce ODTs by direct compression with three advantages: Practical flowability, excellent…
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Sulpiride (SUL) is a dopamine D2-receptor antagonist used for management of GIT disturbance and it has anti-psychotic activities based on the administered dose. SUL undergoes P-glycoprotein efflux, which lead to poor bioavailability and erratic absorption. Therefore, the objective of this research…
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The purpose of this work is to develop an orally disintegrating tablet (ODT) of sildenafil (SIL) using a materials sparing and expedited development approach, enabled by the materials science tetrahedron principle and predictive technologies. To overcome the problem of bitter taste of SIL, an…
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Delivering active ingredients via orally dispersible tablets (ODTs) is a recent trend in the pharmaceutical industry. Due to the easy and fast application, patient’s compliance is high for this kind of dosage form. To ensure a fast drug release, ODTs are typically not coated. Nevertheless, a…
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Orally disintegrating or orally dispersible tablets (ODTs) are dosage forms that disintegrate or dissolve rapidly on contact with saliva. Certain ODTs that are formulated for sustained or controlled release have the ODT attribute of rapid disintegration but do not always undergo rapid dissolution.…
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The aim of this study was to prepare pullulan-based orally disintegrating films (ODFs) containing amlodipine besylate, an anti-hypertensive drug, by the solvent casting method. For this purpose, nine different ODF formulations (F1-F9) were prepared by using different plasticizers (glycerol,…
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Orally disintegrating tablets (ODTs) are one of the most popular dosage forms for improving medication adherence. ODTs disintegrate in saliva in the oral cavity without requiring water. This allows patients with dysphagia, as well as geriatric and pediatric populations, to easily swallow the…
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Paediatric oral formulations need to be improved. This is an indisputable fact that has gain attention from the regulators, the medical staff, and researchers. The lack of adequate medicines developed for children, resulted in several off-label and unlicensed prescriptions, increasing the risks of…
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Performance of orally disintegrating tablets (ODTs) with GRANFILLER-D was investigated by the real-time X-ray observation of water penetration into ODTs. Orally disintegrating tablets (ODTs) have gotten attention as they improve medication adherence for patients who have issues in swallowing,…
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The tensile test is the most widely used method for testing the mechanical characteristics of orally disintegrating films (ODFs). The other available test is the folding endurance (FE) test, which is more suitable for clarifying the actual strength during the manufacturing and dosing. However, the…
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