Pharma Excipients
Orally Dissolving Technology Excipient
Preparation and evaluation of orally disintegrating film containing donepezil for Alzheimer disease
The present study intended to prepare orally disintegrating film (ODF) containing donepezil (DP) for the treatment of mild to moderate alzheimer disease.
HPMC and HPC, glycerine were used as film forming agents, plasticizer, respectively. The ODFs were prepared by solvent casting method. The…
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Development of Robust Orally Dispersible Powder Formulations
The poster on the development of a robust orally dispersible powder formulation for peadiatrics was presented by Graeme Macleod during the EUPFi in Malmö.
See the full Poster of SPI Pharma
The conclusion
ODP formulation requires careful consideration of the excipient properties relative to…
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Microdosed midazolam in a buccal film
Cytochrome P450 3A (CYP3A) isozymes metabolize about 50% of all marketed drugs. Their activity can be modulated up to 400-fold, which has great impact on individual dose requirements for CYP3A substrates. The activity of CYP3A can be monitored using the CYP3A substrate midazolam. To avoid…
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Oromucosal films: From patient centricity to production by printing techniques
Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift…
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Electrospun amorphous solid dispersions of meloxicam: Influence of polymer type and downstream…
The objectives of this work were to develop meloxicam based amorphous solid dispersion through electrospinning technique and evaluate the effect of the polymeric matrix on the physicochemical properties of the fibers and the downstream processing ability to orodispersible dosage forms.
Drug –…
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Dissolution is beautiful – see the wonders of dissolution with new eyes
Testing of pharmaceutical dosage forms can be beautiful!
SOTAX took a closer look at what happens to tablets and capsules when they disintegrate/dissolve and release their API during dissolution tests - and the results are stunning.
Every day thousands of dissolutions tests are performed in…
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Evaluating different manufacturing options to formulate loperamide HCl as orally disintegrating…
Orally disintegrating tablets (ODTs) have become a popular dosage form. Even though formulators have ready-to-use aids on hand, allowing quick and simple drug formulation, some formulations can raise the need for customised formulation development.
Generally, ODTs are fast disintegrating dosage…
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Huperzine a loaded multiparticulate disintegrating tablet
Huperzine A loaded multiparticulate tablet with sustained release was developed to reduce dosing frequency and increase swallowing.
The sustained release was provided by the ethyl cellulose/Poloxamer 127 (EC/F127) microparticles (MPs). F127 was added to facilitate drug release of EC MPs, and the…
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Comprehensive study of co-processed excipients F- Melts®
This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melts® type C, M and F1.
All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were prepared using three compression pressures. The viscoelastic…
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Fast dissolving oral films for drug delivery prepared from chitosan/pullulan electrospinning…
In this study, Chitosan/pullulan composite nanofiber fast dissolving oral films (FDOFs) were prepared via electrospinning technology.
The ratio of chitosan/pullulan (C/P) had an influence on solution property and nanofiber morphology, with the increase of chitosan, viscosity and conductivity of…
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