Pharma Excipients
Orally Dissolving Technology Excipient
Drug delivery through wafer technology: Formulation and manufacturing of buccal and oral…
A great number of patients have difficulty swallowing or needle fear. Therefore, buccal and orodispersible dosage forms (ODFs) represent an important strategy to enhance patient compliance. Besides not requiring water intake, swallowing or needles, these dosage forms allow drug release modulation.…
Read More...
Read More...
“From Powders to Agglomerates” an Overview on Process Technologies and characteristics of the…
Download the Poster or order a Hard Copy (Format Din A0) here
The poster "From Powders to Agglomerates" gives an overview on the different process technologies and processing steps involved for each technology. It also shows the characteristics of the granules including porosity, bulk density, etc.
Read More...
Read More...
Solid lipid particle-based tablets for buccal delivery
This study aims to develop mucoadhesive tablets containing solid lipid particles for controlled release pattern through buccal delivery. The buccal tablets containing drug-loaded solid lipid particles (SLPs) were fabricated using the ultrasonication method and lyophilisation with the incorporation…
Read More...
Read More...
Additive Manufacturing of Personalized Orodispersible Warfarin Films
Warfarin is a narrow therapeutic index drug that requires personalized dosing which is currently not achieved by the marketed products. Further, pediatric and geriatric patients may face swallowing problems with solid oral dosage forms. To face these issues, the aim of the present study was to…
Read More...
Read More...
Ultra–fast disintegrating ODTs comprising viable probiotic bacteria and HPMC as a mucoadhesive
Orodispersible tablets (ODTs) are a convenient dosage form and a recent trend in formulation development. The fast disintegration is accompanied by rapid removal of the active principle and the excipients from the mouth due to saliva flow and swallowing.
Probiotic bacteria are a promising…
Read More...
Read More...
Effect of starch and hydroxypropyl methylcellulose polymers on the properties of orally…
Considering the advantages of orally disintegrating films as alternative pharmaceutical dosage forms, the objective of this work was to develop and evaluate different formulations of orally disintegrating films based on pre-gelatinised starch (%S) and hydroxypropyl methylcellulose (%HPMC), with…
Read More...
Read More...
Designing robust immediate release tablet formulations avoiding food effects for BCS class 3 drugs
Food induced viscosity in the gastrointestinal tract is reported to reduce the bioavailability of tablets containing BCS class 3 drugs, mainly by retarding their disintegration and dissolution of the active pharmaceutical ingredient. The role of formulation factors in minimizing this negative food…
Read More...
Read More...
Development of a dosing device for individualized dosing of orodispersible warfarin films
Individualized medicine is relevant to ensure safe and efficient pharmacotherapy. It requires a suitable dosage form and a matching dosing device to enable flexible dosing serving the needs of individual dose requirements. For oral films no flexible dosing option is available until today. This study…
Read More...
Read More...
How to assess oral dispersible film quality?
In recent years, there has been a tendency toward creating innovative, easy to use and patient-friendly drug delivery systems suitable for every consumer profile, which would ensure safety, stability and acceptability of a drug. One of the relatively novel and promising approaches is the manufacture…
Read More...
Read More...
Potential Use of Magnesium Oxide as an Excipient to Maintain the Hardness of ODTs
This study aimed to clarify the effects of magnesium oxide (MgO) on the hardness of orally disintegrating tablets (ODTs) during storage. ODTs containing a range of MgO concentrations were prepared by direct powder compression and stored for up to 4 weeks in an unpackaged condition at 40°C, with 75%…
Read More...
Read More...