Pharma Excipients
Orally Dissolving Technology Excipient
Multi-particulate formulations: the power of many
After assessing the various routes of drug administration, oral delivery stands out as the safest and, as a result, the most universally accepted among patients. Single-unit dosage forms, including tablets followed by capsules, have been identified as the preferred designs for immediate or modified…
Read More...
Read More...
In Vitro and Biological Evaluation of Oral Fast-Disintegrating Films Containing Ranitidine HCl and…
Flurbiprofen (FBP), a nonsteroidal anti-inflammatory drug (NSAID), is commonly used to treat the pain of rheumatoid arthritis, but in prolonged use it causes gastric irritation and ulcer. To avoid these adverse events of NSAIDs, the simultaneous administration of H2 receptor antagonists such as…
Read More...
Read More...
Taste Masking of Dexketoprofen Trometamol Orally Disintegrating Granules by High-Shear Coating with…
Abstract
Orally disintegrating granules (ODGs) are a pharmaceutical form commonly used for the administration of NSAIDs because of their easy assumption and fast dispersion. The development of ODGs is not easy for drugs like dexketoprofen trometamol (DXKT), which have a bitter and burning taste. In…
Read More...
Read More...
Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate
Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle disorders (UCDs). This study reports on the development of a…
Read More...
Read More...
Novel bioequivalent oral disintegrating tablet of aripiprazole prepared by direct compression…
Herein, we aimed to formulate a novel oral disintegrating tablet (ODT) of aripiprazole (ARP) capable of rapid disintegration using a direct compression technique. Different ODTs were fabricated with directly compressible excipients, and their disintegration time, wettability (water absorption ratio…
Read More...
Read More...
A Novel Handrub Tablet Loaded with Pre- and Post-Biotic Solid Lipid Nanoparticles Combining…
Objective:
This study aimed to develop a holobiont tablet with rapid dispersibility to provide regulation of the microbiota, virucidal activity, and skin barrier protection.
Methods:
A 23 factorial experiment was planned to define the best formulation for the development of the base tablet,…
Read More...
Read More...
Enhancement of dissolution rate and oral bioavailability of poorly soluble drug florfenicol by using…
Abstract
Objective: Florfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability.
Significance: Here in, we aimed to explore the applicability of fast disintegrating tablets compressed from Florfenicol-loaded solid dispersions (FF-SD-FDTs) to improve…
Read More...
Read More...
Development of a New Jelly Coating Technology (Oral Jelly Coating) to Improve Prescribed Medication…
Oral drug delivery is currently the gold standard in the pharmaceutical industry, regarded as the safest, most convenient and most economical method of drug delivery with the highest patient compliance . Among oral formulations, tablets and capsules are the most preferred dosage forms, but there are…
Read More...
Read More...
Manufacturing classification system for oral solid dosage forms of traditional Chinese medicines(Ⅰ):…
Oral solid dosage (OSD) occupies a key position in the market of Chinese patent medicines and new traditional Chinese medicines. Processing route is the foundation for the research and development of traditional Chinese medicine OSDs. On the basis of prescriptions and preparation methods of 1 308…
Read More...
Read More...
Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using…
The use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation of their potential for ODT preparation by 3D printing technology remains almost unexplored. The present study aimed to estimate the use of…
Read More...
Read More...