Pharma Excipients
Orally Dissolving Technology Excipient
Targeted colonic release formulations of mesalazine – A clinical pharmaco-scintigraphic…
Colonic targeting of orally applied therapeutic drugs remains a challenge. Tablet coatings relying on gastrointestinal pH and colonic bacterial enzymes as triggers in association with an inner alkaline layer are expected to improve targeting efficiency. Mesalazine release from three differently…
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An Insight into Preparatory Methods and Characterization of Orodispersible Film—A Review
Over the past few decades, researchers and companies have been trying to develop novel drug delivery systems to ensure safety, efficacy, compliance, and patient acceptability. Nowadays drug discovery and development are expensive, complex, and time-consuming processes, but trends are moving toward…
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Fabrication and Characterization of Orodispersible Composite Film from Hydroxypropylmethyl…
Crosslinked carboxymethyl rice starch (CLCMRS), prepared via dual modifications of native rice starch (NRS) with chloroacetic acid and sodium trimetaphosphate, was employed to facilitate the disintegration of hydroxypropylmethylcellulose (HPMC) orodispersible films (ODFs), with or without the…
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Puzzle out Machine Learning Model-Explaining Disintegration Process in ODTs
Tablets are the most common dosage form of pharmaceutical products. While tablets represent the majority of marketed pharmaceutical products, there remain a significant number of patients who find it difficult to swallow conventional tablets. Such difficulties lead to reduced patient compliance.…
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A Comprehensive Review of Patented Technologies to Fabricate Orodispersible Films: Proof of Patent…
Orodispersible films (ODFs)are ultra-thin, stamp-sized, rapidly disintegrating, and attractive oral drug delivery dosage forms best suited for the pediatric and geriatric patient populations. They can be fabricated by different techniques, but the most popular, simple, and industrially applicable…
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Carbohydrates Used in Polymeric Systems for Drug Delivery: From Structures to Applications
Abstract
Carbohydrates, one of the most important compounds in living organisms, perform numerous roles, including those associated with the extracellular matrix, energy-related compounds, and information. Of these, polymeric carbohydrates are a class of substance with a long history in drug…
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Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible…
Development of orodispersible minitablets (ODMTs) requires consideration of aspects related to small dimensions, while ensuring short disintegration time with sufficient mechanical stability. In order to meet these and other critical quality attributes (CQAs), quality by design is encouraged.…
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Fused Deposition Modeling as a Possible Approach for the Preparation of Orodispersible Tablets
Additive manufacturing technologies are considered as a potential way to support individualized pharmacotherapy due to the possibility of the production of small batches of customized tablets characterized by complex structures. We designed five different shapes and analyzed the effect of the…
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Optimization of diluents on the basis of SeDeM-ODT expert system for formulation development of ODTs…
The present study aimed to optimize diluents characteristics (rheological characteristics, compressibility and disintegration behavior) using SeDeM-ODT expert system, to mask poor characteristics of APIs and will help in development of a formulation which is to be processed by direct compression…
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Machine Learning and Machine Vision Accelerate 3D Printed Orodispersible Film Development
Orodispersible films (ODFs) are an attractive delivery system for a myriad of clinical applications and possess both large economical and clinical rewards. However, the manufacturing of ODFs does not adhere to contemporary paradigms of personalised, on-demand medicine, nor sustainable manufacturing.…
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