Pharma Excipients
Orally Dissolving Technology Excipient
Transfer and scale-up of the manufacturing of orodispersible mini-tablets from a compaction…
Orodispersible mini-tablets (ODMTs) are a promising dosage form for the pediatric use showing increasing interest from pharmaceutical industry. However, a scale-up process for ODMTs from a compaction simulator to a rotary tablet press following FDA and EMA guidelines has not been performed and…
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Evaluation of dissolution techniques for orally disintegrating mini-tablets
Mini-tablets are suitable for paediatric as well as geriatric use since they may provide flexible and accurate dosing and administration. Due to the minute tablet size, there is a need for new standardized quality evaluation procedures and conventional techniques may have to be adopted. The main…
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Study on Applicability of ODTs with Co-processed Excipient to Continuous Manufacturing Process
“Continuous Manufacturing (CM)” is a manufacturing method in which raw or blended materials are continuously charged to the processing line, and products are continuously discharged throughout the duration of the process. CM method is of great significance from the perspective of manufacturing…
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High Acceptability of an Orally Dispersible Tablet Formulation by Children
There is a high unmet medical need for child-appropriate oral dosage forms. The acceptability of a novel placebo orally dispersible tablet formulation (pODT) was therefore evaluated. Monolithic tablets contain an inorganic calcium carbonate/calcium phosphate carrier material as the main excipient.…
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Comprehensive study of co-processed excipients F- Melts®: Flow, viscoelastic and compacts properties
This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melts® type C,M and F1. All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were prepared using three compression pressures. The viscoelastic…
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Design of taste-masked swellable drug particles using dry-coating technology with mechanical curing
A novel dry coating technique for fine particles that does not require any liquids has been developed. Swellable ordered-mixed drug particles (Swell-OM-spheres, SOS), using a modified starch as the core particle and a drug coating layer have been previously developed. In the present work, SOS…
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Development of orally disintegrating tablets containing solid dispersion of a poorly soluble drug…
Diacerein (DCN), a potent anti-inflammatory API used to treat osteoarthritis yet, it suffers from poor water solubility which affects its oral absorption. Unabsorbed colonic DCN is converted into rhein, which is responsible for laxation as a main side effect of DCN treatment. Therefore, in this…
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The evaluation of dynamic compaction analysis as a QbD tool for paediatric orodispersible mini…
The formulation of orodispersible minitablets (ODMTs) usually targets the disintegration time and mechanical strength, but should also consider a series of technological issues related to powder flow and compression behaviour. In this regard, the present study aimed to evaluate the contribution of…
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In vitro characterization and mouthfeel study of functionalized calcium carbonate in orally…
Orally disintegrating tablets (ODT) are comfortable and safe drug delivery methods beneficial for all age groups of patients. ODTs are characterized by fast disintegration, high physical stability, taste masking and acceptable mouthfeel. In this work, the applicability of Functionalized Calcium…
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Investigation of hydroxypropyl-β-cyclodextrin inclusion complexation of two poorly soluble model…
The goal for any formulation design of poorly soluble drugs is to increase the solubility. However, increased solubility is a challenge when the drug is administered to the oral cavity as rapidly dispersing or mucoadhesive buccal films. Most drugs are bitter and increased solubility may correlate…
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