Pharma Excipients
Organic Chemicals
Actual Sugars
Artificial Sweeteners
Carbohydrates
Cellulose
Cellulose Esters
Cellulose Ethers
CMC and Croscarmellose Sodium
Converted Starch
Dried Starch
Ethyl Cellulose
HPC - hydroxypropyl cellulose
HPMC - Hydroxypropylmethylcellulose
Microcrystalline Cellulose
Modified Starch
Starch
Sugar Alcohols
Sugars
Trehalose
Tablet ejection: A systematic comparison between force, static friction, and kinetic friction
The magnitude of the frictional forces during the ejection of porous pharmaceutical tablets plays an important role in determining the occurrence of tabletting defects. Here, we perform a systematic comparison between the maximum ejection force, static friction coefficient, and kinetic friction…
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Formulation and dermal delivery of a new active pharmaceutical ingredient in an in vitro wound model…
The aim of this study was to investigate dermal delivery of the new active pharmaceutical ingredient (API) TOP-N53 into diabetic foot ulcer using an in vitro wound model consisting of pig ear dermis and elucidate the impact of drug formulation and wound dressing taking into consideration clinical…
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Analysis of the impact of material properties on tabletability by principal component analysis and…
Principal component analysis (PCA) and partial least squares regression (PLS) were combined in this study to identify key material descriptors determining tabletability in direct compression and roller compaction. An extensive material library including 119 material descriptors and tablet tensile…
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A modified mechanistic approach for predicting ribbon solid fraction at different roller compaction…
Abstract
This research investigates the modeling of the pharmaceutical roller compaction process, focusing on the application of the Johanson model and the impact of varying roll speeds from 1 to 15 RPM on predictive accuracy of ribbon solid fraction. The classical Johanson’s model was integrated…
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An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of…
Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate. However, most new chemical entities exhibit poor water solubility, and hence are exempt from such benefits. Although combining drug amorphization with…
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Real-time release testing of in vitro dissolution and blend uniformity in a continuous powder…
Abstract
Continuous manufacturing is gaining increasing interest in the pharmaceutical industry, also requiring real-time and non-destructive quality monitoring. Multiple studies have already addressed the possibility of surrogate in vitro dissolution testing, but the utilization has rarely been…
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The development of an innovative method to improve the dissolution performance of rivaroxaban
Abstract
Recent advancements in the formulation of solid dosage forms involving active ingredient-cyclodextrin complexes have garnered considerable attention in pharmaceutical research. While previous studies predominantly focused on incorporating these complexes into solid states, issues…
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The influence of milling of ribbons on selected granule quality attributes and carvedilol release…
Abstract
Roller compaction is gaining importance in the pharmaceutical industry. This study evaluates the impact of ribbon milling conditions on properties of granules and compression mixtures and on drug release from hypromellose-based matrix tablets prepared with two different fillers. In the…
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Nordic Bioproducts Group Receives Pharmaceutical Industry’s EXCiPACT™ Certification for MCC…
Press Release
The Finnish company’s new factory in Lappeenranta has received the prestigious certification after being thoroughly audited by a recognized international entity. Nordic Bioproducts Group’s product offers the perfect solution for the pharmaceutical industry, combining quality and…
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Formulation and Evaluation of Polysaccharide Microparticles for the Controlled Release of…
Abstract
Propranolol hydrochloride, a non-cardio-selective beta blocker, is used to treat several conditions in children, including hypertension, arrhythmias, hyperthyroidism, hemangiomas, etc. Commercial liquid formulations are available in Europe and the US, but they have disadvantages, such as…
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