Pharma Excipients
Cellulose Ethers
Improving the drug load and in vitro performance of supersaturated self-nanoemulsifying drug…
In this study, the influence of the polymeric precipitation inhibitor (PPI) PVP/VA 64 (polyvinylpyrrolidone-co-vinyl acetate) on the physical stability and in vitro performance of supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) containing the model drug simvastatin (SIM) was…
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Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic…
In this study, the abilities of hydroxypropyl methylcellulose (HPMC) and methylcellulose (MC) as nonionic surfactants to improve the dissolution rate of carvedilol solid dispersions (CAR SDs) with Kollicoat IR as a carrier were clearly demonstrated.
CAR SDs were prepared using the solvent…
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DuPont Smart Pharma Solutions: Essential Excipients and Vital Expertise
DuPont aims to help their pharma customers overcome everyday challenges and innovate future solutions. Armed with essential excipients and vital expertise, the broad portfolio is designed to deliver performance and cost advantages in various oral solid dosage forms. Couple that with leading QbD…
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Determinants of zero-order release kinetics from acetaminophen-layered Suglet® pellets,…
The potential for zero-order drug-release was evaluated for ethyl cellulose (EC) coated, acetaminophen-layered sugar pellets (Suglets®) of mesh size 18/20 (850–1000 μm).
To determine optimal plasticizer/pore-former concentrations for EC films, solvent-cast Aquacoat® ECD (ethyl cellulose…
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Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffold
From a patient-centric perspective, oromucosal drug delivery is highly attractive due to the ease of administration without the need of swallowing, and improved patient safety.
The aim of the presented work was to prepare a buccal film using a self-forming micellar drug solubiliser as the film…
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Novel in situ gelling ophthalmic drug delivery system based on gellan gum and hydroxyethylcellulose
Achieving drug delivery at the ocular level encounters many challenges and obstacles.
In situ gelling delivery systems are now widely used for topical ocular administration and recognized as a promising strategy to improve the treatment of a wide range of ocular diseases. The present work…
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Incorporation of HPMCAS during loading of glibenclamide onto mesoporous silica improves dissolution…
Mesoporous silica has emerged as an enabling formulation for poorly soluble active pharmaceutical ingredients (APIs).
Unlike other formulations, mesoporous silica typically does not inhibit precipitation of supersaturated API therefore, a suitable precipitation inhibitor (PI) should be added to…
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Preparation and dissolution characteristic evaluation of carvedilol-Kollicoat IR solid dispersions…
In this study, the abilities of hydroxypropyl methylcellulose (HPMC) and methylcellulose (MC) as nonionic surfactants to improve the dissolution rate of carvedilol solid dispersions (CAR SDs) with Kollicoat IR as a carrier were clearly demonstrated.
CAR SDs were prepared using the solvent…
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Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based…
Pharmaceutical applications of three dimensional (3D) printing technology are increasing following the approval of 3D-printed tablets by the U.S. Food and Drug Administration.
Semi-solid extrusion-type 3D printers are used to 3D print hydrogel- and paste-based materials. We previously developed…
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Development of conjugate-by-conjugate structured nanoparticles for oral delivery of docetaxel
In the current study, we developed interpolymer-complex structures composed of hydroxypropyl methylcellulose (HPMC) and chitosan knitted with d-α-tocopherol polyethylene glycol succinate (TPGS) to establish oral nanoparticle delivery systems that could keep the drug dose from releasing into the…
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