Cellulose Ethers

Formulation of lipid-based drug delivery systems is recognized as a promising strategy to increase bioavailability of simvastatin (SV). The purpose of this study was to formulate advantageous lipid-based drug delivery systems for pH-controlled release of SV using polymethacrylate polymers…
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Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift…
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In this work, we report new formulations for the combined photo-chemotherapy of colon cancer. Fibers were fabricated via coaxial-electrospinning with the intent of targeting delivery of the anti-cancer drug carmofur (CAR) and the photosensitizer rose bengal (RB) selectively to the colon site. The…
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The objective of this study was to investigate the applicability of water-insoluble polymers as binders for pellets drug layering to extend the drug release. Carbamazepine was layered on sugar cores in fluidized bed coater using isopropanol (IPA):water solution or aqueous dispersion of…
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The subdivision behavior of polymeric tablets produced with the well-known polymers Soluplus® (SOL), polyvinyl pyrrolidone co-vinyl acetate (PVPVA) and hydroxypropyl methylcellulose (HPMC) was evaluated in this study. The polymeric tablets were submitted to different post-treatments (aging,…
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Huperzine A loaded multiparticulate tablet with sustained release was developed to reduce dosing frequency and increase swallowing. The sustained release was provided by the ethyl cellulose/Poloxamer 127 (EC/F127) microparticles (MPs). F127 was added to facilitate drug release of EC MPs, and the…
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It was the aim of the study to assess in vitro methods for the characterization of mucoadhesive hydrogels for their potential to predict the residence time on human buccal mucosa. Methods Mixtures of hydrogels comprising hydroxyethyl cellulose (HEC), sodium carboxymethyl cellulose (CMC),…
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Premium ethylcellulose polymers are hydrophobic cellulose ether based biomaterials widely employed as biocompatible templates for the design of novel drug delivery systems. They are classified as United States Food and Drug Administration Generally-Recognized-As-Safe chemical substances and have…
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In spite of the major advantages that the liquisolid technology offers, particularly in tackling poor bioavailability of poorly water-soluble drugs (i.e., BCS Class II drugs), there are a few critical drawbacks. The inability of a high liquid load factor, poor flowability, poor compactibility,…
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Wurster coater was utilized for coating glass beads with HPMC/PEG. The effects of design and operating parameters on the coating process were evaluated. It was found that the pressure drop decreases when spraying the coating solution into the bed, indicating that spraying prevents the particles…
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