Pharma Excipients
Cellulose Ethers
Screening of Sacrificial Excipients for Arresting Devitrification of Itraconazole from Solid…
The aim of the present investigation was to develop a solid dispersion of itraconazole (ITR) using sacrificial excipients like pregelatinized starch and spray-dried lactose alongside hydroxypropyl methylcellulose and Poloxamer 188, thereby arresting the conversion of the amorphous form of ITR to…
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3D printing and characterization of hydroxypropyl methylcellulose and methylcellulose for…
The currently available support materials used with 3D printing technology have challenges of poor dissolvability in chemical solution and difficulty to be removed from the finished part. Current support materials are usually petroleum based which has a negative impact on the environment.
The…
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Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary…
Pulmonary delivery of vasodilators is a promising alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). The aim of this study was to design and evaluate hydrogel microparticles as a carrier for sustained pulmonary delivery of sildenafil citrate. Spray dried…
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Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded…
The aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation. Therefore, a quality by design approach was implemented to model the effect of the process parameters of…
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Ultra–fast disintegrating ODTs comprising viable probiotic bacteria and HPMC as a mucoadhesive
Orodispersible tablets (ODTs) are a convenient dosage form and a recent trend in formulation development. The fast disintegration is accompanied by rapid removal of the active principle and the excipients from the mouth due to saliva flow and swallowing.
Probiotic bacteria are a promising…
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DNA scaffold nanoparticles coated with HPMC/EC for oral delivery
The control of the glycemic level among diabetes/T2 patients is very important for their long term survival and avoiding further complexities including micro/macrovascular diseases as well as diabetic neuropathy. Vildagliptin (VD) is a drug that has addressed these issues successfully with the…
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Drug-carrier binding and enzymatic carrier digestion in amorphous solid dispersions containing…
In order to further explain the ability of gelatin 50PS and bovine serum albumin (BSA) to generate supersaturation of a series of poorly soluble drugs (carbamazepine, cinnarizine, diazepam, itraconazole, nifedipine, indomethacin, darunavir (ethanolate), ritonavir, fenofibrate, griseofulvin,…
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Effect of starch and hydroxypropyl methylcellulose polymers on the properties of orally…
Considering the advantages of orally disintegrating films as alternative pharmaceutical dosage forms, the objective of this work was to develop and evaluate different formulations of orally disintegrating films based on pre-gelatinised starch (%S) and hydroxypropyl methylcellulose (%HPMC), with…
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Quality-by-Design based development and characterization of pioglitazone loaded liquisolid compact…
The present research work describes the formulation development of liquisolid compact tablets of pioglitazone for improving its dissolution performance and antidiabetic activity. Using Quality by Design (QbD) approach, a total of nine formulations were prepared as per the central composite design…
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Development of a dosing device for individualized dosing of orodispersible warfarin films
Individualized medicine is relevant to ensure safe and efficient pharmacotherapy. It requires a suitable dosage form and a matching dosing device to enable flexible dosing serving the needs of individual dose requirements. For oral films no flexible dosing option is available until today. This study…
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