Pharma Excipients
Cellulose Ethers
3D-Printed Isoniazid Tablets for the Treatment and Prevention of Tuberculosis—Personalized Dosing…
The aim of the present work was to produce 3D-printed oral dosage forms with a sufficient drug dose displaying various release profiles. Hot-melt extrusion was utilized to produce drug-loaded feedstock material that was subsequently 3D-printed into 6, 8, and 10 × 2.5 mm tablets with 15% and 90%…
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Edible solid foams as porous substrates for inkjet-printable pharmaceuticals
The aim of this study was to investigate new porous flexible substrates, i.e., solid foams that would serve as a carrier with a high ink absorption potential for inkjet printable pharmaceuticals. Propranolol hydrochloride was used as a model active pharmaceutical ingredient (API). Pharmaceutically…
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Sustainable Application of Biopolymer
The widespread use of materials produced from petrochemical substrates, such as plastics, can exert an adverse impact on the environment, especially on creatures living therein, including fish and turtles in the sea, as well as the birds inhabiting the vicinity that may die from mistaking plastics…
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Formulation and evaluation of fluconazole loaded oral strips for local treatment of oral candidiasis
This study aimed to develop fluconazole loaded buccal mucoadhesive oral strip for local treatment of oral candidiasis. Oral strip was prepared by solvent casting method with different polymer combinations and evaluated for weight, thickness, drug content, tensile strength, swelling behavior, in…
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Effect of binder and load solubility properties on HPMC granules produced by wet granulation process
Hydroxypropyl methylcellulose (HPMC) is one of the most important hydrophilic ingredients used in hydrogel matrices preparation (tablets or granules). In this work, HPMC was used to produce granules loaded with hydrophilic and hydrophobic active molecules to investigate their possible use as release…
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Understanding the release performance of pellets with hydrophobic inclusions in sustained-release…
The aim of this study was to evaluate how the addition of hydrophobic inclusions to sustained-release pellet film coat can affect drug release. Sustained-release formulations, in particular multiparticulate systems are gaining popularity because they are able to reduce the dosing frequency of drugs…
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Formulation of Dispersed Gliclazide Powder in Polyethylene Glycol–Polyvinyl Caprolactam– Polyvinyl…
Background: Oral bioavailability of gliclazide, a hypoglycemic drug, is hindered by its low aqueous solubility. Improvement of solubility will enhance dissolution rate and in turn the bioavailability. This research aimed to formulate the solid dispersed gliclazide using a novel polyethylene…
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Optimization of Nasal Drug Absorption from Powder Formulations: The Feasibility of Controlling Drug…
Nasal application of powder formulations has garnered attention because of its significant potential for systemic drug delivery. Because a powder drug must first diffuse from the formulation and dissolve in the nasal cavity fluid before transepithelial permeation, dissolution and diffusion are…
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Probing the impact of HPMC viscosity grade and proportion on the physical properties of…
This study investigated the impact of hydroxypropyl methylcellulose (HPMC) viscosity grade, HPMC proportion and particle size fraction on the physical properties of the freeze-dried mannitol-HPMC excipients produced, using multivariate analysis methods. Solutions containing 20 %, w/w mannitol-HPMC…
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Chemically identical but physically different: a comparison of spray drying, hot melt extrusion and…
In spite of the large research efforts in the past two decades, it is still difficult, if possible at all, to predict what manufacturing technology will lead to the best amorphous solid dispersions (ASDs) in terms of drug to polymer ratio (“drug loading”) and physical stability. In general, ASDs can…
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