Pharma Excipients
Cellulose Ethers
Enhancement of saquinavir absorption and accumulation through the formation of solid drug…
Nanotechnology is now considered a promising drug delivery method for orally administered hydrophobic drugs to their sites of action. The effect of nanodispersion on cellular transport and accumulation of saquinavir (SQV) was investigated.
Methods
The transport of five solid drug…
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Thermodynamic and kinetic evaluation of the impact of polymer excipients on storage stability of…
Two pharmaceutical polymers with high glass transition temperatures (Tg>100°C), polyvinylpyrrolidone-vinyl acetate copolymer (PVPVA) and hydroxypropyl methylcellulose acetate succinate (HPMCAS), have been assessed for their impact on the storage stability of itraconazole (ITZ) amorphous solid…
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A Feasibility Study on HPMC-Improved Sulphoaluminate Cement for 3D Printing
A novel 3D printing material based on hydroxypropyl methylcellulose (HPMC)—improved sulphoaluminate cement (SAC) for rapid 3D construction printing application is reported. The hydration heat, setting time, fluidity of paste and mortar, shape retainability, and compressive strength of extruded SAC…
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A Big Data Approach to Pharmaceutical Flow Properties
Flowability is a key consideration during the formulation and process development of oral solid dosage forms as it can have a critical impact on product quality. With a limited number of examples available in the literature, there is a need to better understand and share the typical flow properties…
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A comparison of drum granulation of biochars
Drum granulation can be used to form biochar granules that could reduce dust hazards during biochar application to soils. An investigation of the effect of operational parameters using three biochar feedstock was conducted to identify the effect of biochar feedstock on granule properties. Cornstalk,…
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Testosterone- and vitamin-grafted cellulose ethers for sustained release of camptothecin
Camptothecin (CPT), a potent anticancer drug with known antiviral activity, is halted of clinical use. Few drug delivery systems of CPT are approved for therapy. Hereby, we propose the encapsulation of hydrophobic CPT in the inner core of cellulose nanoaggregates for sustained release with retaining…
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Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid…
3D-printing is a promising tool to pave the way to the widespread adaption of individualized medicine. Several printing techniques have been investigated and introduced to pharmaceutical research. Until now, only one 3D-printed medicine is approved on the US market. The medicine is manufactured via…
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Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films
In this work hydroxypropyl methylcellulose (HPMC) fast-dissolving thin films for oral administration are investigated. Furosemide (Class IV of the Biopharmaceutical Classification System) has been used as a model drug for in vitro release tests using three different set-ups: the Franz cell, the…
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Application of natural polymers as pharmaceutical excipients
The use of natural polymer as excipients in pharmaceutical sector is expanding day by day. Low cost, safety degradable are the main causes that make them differ from other sources. Natural sources have wide range of varieties and characteristics. So they can be used…
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Effects of Different Polymers on Thermal Inkjet Printing of Oral Thin Films: A Novel Approach
The aim of this research was to use inkjet printing technology in formulation of personalized medicine. Thus in this research, an attempt was made to print OTF by TIJ printing. A placebo solution comprising of different polymers and polymer concentrations was used for TIJ printing on A4 paper. The…
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