Pharma Excipients
Cellulose Ethers
Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid…
Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods.…
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Prolonged release from orodispersible films by incorporation of diclofenac-loaded micropellets
Prolonged drug release provided by multiple-unit dosage forms is highly beneficial to enhance the compliance and safety of the pharmacotherapy even for patients with swallowing deficiencies. To facilitate the intake for these patients, multiple-unit tablets and capsules have to be crushed or opened.…
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Relationship between amorphous solid dispersion In Vivo absorption and In Vitro dissolution
Enzalutamide is a fast crystallizing, hydrophobic compound that has solubility limited absorption in vivo. Given the low aqueous solubility of this compound, it was of interest to evaluate amorphous formulations in vitro and in vivo. Amorphous solid dispersions (ASD) of enzalutamide were prepared…
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Efficient Mucosal Immunization by Mucoadhesive and pH-Sensitive Polymeric Vaccine Delivery System
Mucosal surfaces as the largest immune organ of human body cover 400 m2 of the body including the gastrointestinal, urogenital, and respiratory tracts. The local mucosal immunity is an important first line of defense against many pathogens because most pathogens initiate their infection through…
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A Statistical Determination of the Contribution of Viscoelasticity of Aqueous Carbohydrate Polymer…
In this study the relationship between the viscoelasticity/mechanical properties of metronidazole-containing aqueous polymer networks composed of HEC and PVP and drug release was statistically modelled. The networks were characterised using oscillatory analysis and drug release was performed using…
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An introduction to pharmaceutical film coatings
A wide variety of pharmaceutical products, including pellets, granules, capsules, powders, and crystals are often film coated. In this present article, we will concentrate on the film-coating of tablets.
The procedure of coating tablets is a complex process that results in the forming of a thin…
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Development of high drug loaded pellets by Design of Experiment and population balance model…
Medicines of drug coated inert pellets filled into hard capsules or compressed into tablets are already on the market, until now, their number is limited and there are few systematic investigations of possible coating amounts. Pellets of microcrystalline cellulose were coated with a model drug…
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A platform direct compression formulation for low dose sustained-release tablets enabled by a dual…
Content uniformity (CU) is a well-recognized challenge for low-dose direct compression (DC) tablet formulations. Using a dual particle engineering approach that involves a) forming a segregation-resistant drug-carrier composite to improve CU and b) nanocoating HPMC to enhance flowability, we have…
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Water-soluble and -insoluble polymers as binders for pellet preparation by extrusion/spheronization
The objective of this study was to investigate the effect of binder (water-soluble vs. -insoluble) and granulation fluid (aqueous vs. organic) on the physical properties of pellet prepared by extrusion/spheronization and on drug release. Size distribution, sphericity, bulk density, crushing force…
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Preparation of a solid self-microemulsifying drug delivery system by hot-melt extrusion
Hot-melt extrusion (HME) has gained increasing attention in the pharmaceutical industry; however, its potential in the preparation of solid self-emulsifying drug delivery systems (S-SMEDDS) is still unexplored. This study sought to prepare enteric S-SMEDDS by HME and evaluate the effects of the…
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