Pharma Excipients
Cellulose Ethers
Formulation design of hydroxypropyl cellulose films for use as orally disintegrating dosage forms
08. May 2018 Hydroxypropyl cellulose (HPC) is a water-soluble polymer used as a binder during pharmaceutical tableting and granulation. HPC is also known as a base material for pharmaceutical film by virtue of its film formability…
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A novel approach to support formulation design on twin screw wet granulation technology:…
The overall objective of this work is to understand how excipient characteristics influence the drug product quality attributes and process performance of a continuous twin screw wet granulation process. The knowledge gained in this study is intended to be used for Quality by Design (QbD)-based…
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Differences in properties of HPMC co-processed fillers prepared by fluid-bed coating and spray…
11. April 2018 This study aimed to develop novel co-processed tablet fillers based on the principle of particle engineering for direct compaction and to compare the characteristics of co-processed products obtained by fluid-bed…
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Flow, compaction and tabletting properties of co-processed excipients using pregelatinized Ofada…
31. March 2018 The growing popularity of direct-compression process necessitates an ideal filler–binder that can substitute two or more excipients. Pregelatinization of starches significantly improves swelling and flow properties…
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A Novel Approach for Dry Powder Coating of Pellets with Ethylcellulose
19. February 2018 The objective of this study was to assess the efficacy and the capability of a novel ethylcellulose-based dry-coating system to obtain prolonged and stable release profiles of caffeine-loaded pellets. Lauric and…
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Improved HPMC films by incorporation of amylose-sodium palmitate
07. February 2018
Abstract
Polymer film blends of hydroxypropyl methylcellulose (HPMC) and amylose-sodium palmitate inclusion complexes (Na-Palm) were produced with no plasticizer, and were observed to have improved physical and gas barrier properties as compared with…
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Nano-sized solid dispersions based on hydrophobic-hydrophilic conjugates
29. September 2017 The aim of this study was to investigate hydrophilic-hydrophobic conjugates as new carriers for nano-sized solid dispersions (SDs). The amphiphilic conjugates were prepared via an esterification reaction between…
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Comparative impact of different binder addition methods, binders and diluents on resulting granule…
21. July 2017 Abstract This study investigated comparative impact of different binder addition methods (pouring, dripping, spraying), binders and diluents on resulting granule and tablet attributes via high shear wet…
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Co-spray Drying with HPMC as a Platform to Improve Direct Compaction Properties of Various Tablet…
24. May 2017 Abstract Many commonly used tablet fillers are not suitable for direct compaction process due to insufficient properties, mainly of flowability and compactability. This work therefore aimed to use co-spray drying…
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Optimization of film-coating formulation containing a novel low molecular weight hypromellose to…
28. April 2017 Abstract In recent years, a novel low molecular weight hypromellose (hypromellose 2906, VLV hypromellose) was developed to improve tablet-coating process and lower costs in the pharmaceutical industry. Such VLV…
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