Pharma Excipients
Cellulose Ethers
Film forming systems for topical and transdermal drug delivery
Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression. The use of alginic acid as an excipient in tablet formulation is limited because of certain drawbacks such as low tablet hardness and poor compressibility. The…
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Novel high-drug-loaded amorphous dispersion tablets of posaconazole
Amorphous solid dispersions (ASDs) can increase bioavailability of drugs with poor aqueous solubility. However, concentration-sustaining dispersion polymers (CSPs) incorporated in ASDs can result in low drug loading and therefore large dosage-form size or multiple units to meet dose requirements,…
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Polymer Selection for Hot-Melt Extrusion Coupled to Fused Deposition Modelling in Pharmaceutics
Three-dimensional (3D) printing offers the greatest potential to revolutionize the future of pharmaceutical manufacturing by overcoming challenges of conventional pharmaceutical operations and focusing design and production of dosage forms on the patient’s needs. Of the many technologies…
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METHOCEL™ Cellulose Ethers – versatile excipients in continuous production and many other…
Did you know that the METHOCEL™ products have been in continuous production for more than 70 years with facilities and deep polymer expertise from our experts located around the globe. Find out more about what this polymer delivers in pharma applications.
METHOCEL™ cellulose ethers are…
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A Semi-Dissolving Microneedle Patch Incorporating TEMPO-Oxidized Bacterial Cellulose Nanofibers for…
Although dissolving microneedles have garnered considerable attention as transdermal delivery tools, insufficient drug loading remains a challenge owing to their small dimension. Herein, we report a one-step process of synthesizing semi-dissolving microneedle (SDMN) patches that enable effective…
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DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible…
The development of new bio-based inks is a stringent request for the expansion of additive manufacturing towards the development of 3D-printed biocompatible hydrogels. Herein, methacrylated carboxymethyl cellulose (M-CMC) is investigated as a bio-based photocurable ink for digital light processing…
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How to Clean Sustained-Release Polymers
by Priya Poduval | July 22, 2020
Solubilizing SR excipients are difficult unless solvents are used for cleaning. Most of the companies using this method have a similar cleaning process – manual application using a lint-free wipe followed by vigorous scrubbing. Although this is effective, it is…
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Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of…
Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase. In recent years, it has been shown that tolcapone is a potent inhibitor of…
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Biopharmaceutical implications of excipient variability on drug dissolution from immediate release…
Elucidating the impact of excipient variability on oral product performance in a biopharmaceutical perspective would be beneficial and allow excipient implementation on Quality by Design (QbD) approaches. The current study investigated the impact of varying viscosity of binders (hypromellose (HPMC))…
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Jet lag treatment with controlled release melatonin and caffeine
Multi-particulate Dome matrix with sustained-release melatonin and delayed-release caffeine was designed to restore jet lag sleep-wake cycle. The polymeric pellets were produced using extrusion-spheronization technique and fluid-bed coated when applicable. The compact and Dome module were produced…
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