Pharma Excipients
Cellulose Ethers
Solubility Improvement of Progesterone from Solid Dispersions Prepared by Solvent Evaporation and…
The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC), hydroxypropyl methylcellulose acetate…
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Zein as a water insoluble excipient for spray dry encapsulation of hydrophilic bioactives
Anti-solvent precipitation of zein was employed in conjunction with spray drying to reduce the usage of ethanol and to encapsulate the aqueous extract of green jelly leaf (Cyclea barbata Miers) antioxidants. Different concentrations of zein (0.35, 0.7, 1.05 and 1.4% w/v) and Hydroxypropylmethyl…
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Screening of stabilizing agents to optimize flurbiprofen nanosuspensions using experimental design
Although flurbiprofen (FB), as one of non-steroidal anti-inflammatory drugs, has various pharmacological applications, it shows low dermal bioavailability due to its low water solubility. To overcome this solubility problem, FB nanosuspensions were developed and the effects of stabilizers were…
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Novel approach to evaluating granulation and segregation level considering the contribution of…
The granulation process is critical to the uniformity of not only the active ingredient (API) but also other excipients in granules. Insufficient granulation results in unexpected product quality, e.g. delayed dissolution and lack of uniformity of API. Therefore, evaluating the granulation and…
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Elastic recovery in roll compaction simulation
Roll compaction/dry granulation is a widely used granulation method in the pharmaceutical industry. The simulation of the process is of great interest, especially in the early phase of formulation development of solid dosage forms. The hybrid modeling approach allows to predict the roll compaction…
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Effect of the third component on the aging and crystallization of cinnarizine-soluplus® binary solid…
Multiple carriers may be used to prepare solid dispersions (SDs) for different purposes. The aim of this work is to investigate the effect of the third component on the physical stability and physical aging behavior of cinnarizine-soluplus SDs. HPMC, PVP, sorbitol and citric acid were used as the…
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Development of an Orodispersible Film Containing Stabilized Influenza Vaccine
Most influenza vaccines are administered via injection, which is considered as userunfriendly. Vaccination via oral cavity using an orodispersible film (ODF) might be a promising alternative. To maintain the antigenicity of the vaccine during preparation and subsequent storage of these ODFs, sugars…
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Mucoadhesive Buccal Films for Local Delivery of Lactobacillus brevis
The aim of this work was to prepare mucoadhesive buccal films for local release of Lactobacillus brevis CD2, which shows interesting anti-inflammatory properties due to its high levels of arginine deiminase. Hydroxypropylmethylcellulose-based films were prepared by means of a modified casting…
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Influence of cellulose and acetate-based polymers on the release of ciprofloxacin hcl from extended…
The objectives of the current study were to investigate the influence of different types and concentration of polymers on release of ciprofloxacin HCl as well as to formulate an extended release tablets of ciprofloxacin hydrochloride by direct compression method. Twelve formulations (F1 – F12) were…
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Ethylcellulose-based drug nano depots fabricated using a modified triaxial electrospinning
New strategies based on advanced technologies are highly desired for expanding the applications of biological macromolecules in the applied scientific fields. In the present study, a new kind of core-shell nano depots were designed, in which the shell section was a drug-polymer composite and the…
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