Pharma Excipients
Cellulose Ethers
INFLUENCE OF BINDER ATTRIBUTES ON BINDER EFFECTIVENESS IN A CONTINUOUS TWIN SCREW WET GRANULATION…
As a switch to continuous twin screw granulation is quickly gaining momentum, the suitability of binders needs to be evaluated towards this novel granulation process. Binder suitability depends on binder effectiveness, which is affected by binder attributes. These critical attributes need to be…
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Continuous twin screw granulation: A complex interplay between formulation properties, process…
Due to the numerous advantages over batch manufacturing, continuous manufacturing techniques such as twin screw wet granulation are rapidly gaining importance in pharmaceutical production. Since a large knowledge gap on the importance of formulation variables exists, this study systematically…
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Data on the drug release profiles and powder characteristics of the ethyl cellulose based…
Ethyl cellulose (EC) based microparticles (MPs) could provide sustained release for Huperzine A. The drug release mechanism of MPs was exploited to achieve an ideal drug release profile. We previously found that the wettability of MPs greatly contributed to facilitating drug release, which was…
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Simplification of Fused Deposition Modeling 3D-Printing Paradigm: Feasibility of 1-step Direct…
Direct powder three-dimensional (3D)-printing (DPP) of tablets to simplify fused deposition modelling (FDM) was explored. The FDM paradigm involving hot-melt extrusion for making 3D-printable drug-loaded filaments as intermediate products for tablet manufacturing has been gaining attention for the…
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Polymers for Extrusion‐Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process…
Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of ʹone size fits for allʹ. Using 3D printing, it is possible to design and develop complex dosage forms that can…
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Taste Masking Coating of Mini-Tablets with Cellulose Derivatives: Formulation and Analytical…
You wonder how to improve tablets swallowability and taste? Look at the poster describing solutions with HPMCAS (Shin-Etsu AQOAT®) and L-HPC from their originator, Shin-Etsu.
Download the Poster as a pdf here: Taste Masking Coating of Mini-Tablets with Cellulose Derivatives- Formulation and…
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Interfacial bonding in formulated bilayer tablets
To take full advantage of the drug delivery benefits offered by bilayer tablets, the common issue of weak interfacial bonding strength (IBS) with manufacturing must be overcome. This work seeks to characterize the effects of composition in individual layers and compaction pressure on the IBS.…
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Quantification of porogen effect on the drug release from single- and multi-layered ethylcellulose…
The aim of this work was to develop a mathematical model to estimate the drug release from a conventional single-compartment reservoir pellet and extend its applicability to multi-compartment reservoir pellets. Conventional pellets were prepared by layering the drug onto starter-core then applying…
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Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid…
Drug delivery of poorly soluble drugs in form amorphous solid dispersions (ASDs) is an appealing method to increase in vivo bioavailability. For rational formulation design, a mechanistic understanding of the impact of surfactants on the performance of ASD-based formulations is therefore of…
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Continuous twin screw granulation: impact of binder addition method and surfactants on granulation…
Despite the recent commercialization of several drug products manufactured through continuous manufacturing techniques, knowledge on the formulation aspect of these techniques, such as twin screw wet granulation, is still rather limited.
Previous research identified lactose/MCC/HPMC as a robust…
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