Pharma Excipients
Cellulose
Impact of method of preparation of Amorphous Solid Dispersions on Mechanical Properties: Comparison…
Usage of the amorphous phase of compounds has become the method of choice to overcome oral bioavailability problems related to poor solubility. Due to the unstable nature of glasses, it is clear that the method preparation of the amorphous glass will have an impact on physical/chemical stability…
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Effects of pharmaceutical processes on the quality of ethylcellulose coated pellets: Quality by…
The main purpose of this study was to investigate the influence of ethylcellulose (EC) coating and curing conditions on the quality attributes of pharmaceutical pellets prepared using a quality bydesign (QbD) approach. The drug release rate of methimazole, a freely soluble model drug, was evaluated…
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Microcrystalline cellulose, lactose and lignin blends: Process mapping of dry granulation via roll…
07. July 2018
In this study, a process map was developed in an effort to improve the understanding of dry granulation of pharmaceutical excipients by roll compaction process, and to implement the quality-by-design(QbD) approach. Through development of the process map, a…
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Application of hydroxypropyl methylcellulose as a protective agent against magnesium stearate…
20. June 2018
Itraconazole is a fungicide drug which has low bioavailability due to its poor water solubility. Amorphous solid dispersion (ASD) is a tool that has the potential to greatly increase the dissolution rate and extent of compounds. In this work, the…
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Surface engineered excipients:II. Simultaneous milling and dry coating for preparation of fine-grade…
15. May 2018 Asolventless process for simultaneously milling and dry coating microcrystalline cellulose (MCC) was investigated for producing fine excipients in five different sizes (∼20, 25, 30, 35, 40µm) havinghigh bulk density…
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Evaluation of Non-Crystalline Cellulose as a Novel Excipient in Solid Dose Products
12. May 2018 The objective of this study was to evaluate non-crystalline cellulose (NCC) as a novel tablet excipient in solid oral dosage forms in comparison with microcrystalline cellulose (MCC) and silicified microcrystalline…
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Variability in Excipients: Tylose in Microcrystalline Cellulose
26. March 2018 Compatibility of excipients in drug products is demonstrated in accelerated and real-time stability programs, but too often batch-to-batch variability of excipients is ignored. Many excipients are derived through…
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Lornoxicam Immediate Release Tablet Using Spray-Dried Cellulose Nanofibers (NFC) as Novel Tablet…
30. September 2016
Abstract: The choice of proper excipients is one of the key factors for successful formulation of pharmaceutical dosage forms. Increasing number of new therapeutic compounds suffers from poor solubility and/or bioavailability, creating a challenge from…
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A MALLEABLE TECHNIQUE FOR FUTURE COATING PROCESS–SOLVENTLESS COATING
06. April 2016 Coatings are a vital part in the formulation of pharmaceutical dosage form to attain grander aesthetic quality, physical and chemical protection for the drugs in the dosage forms, and modification of drug release…
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INFLUENCE OF INTERFACIAL AND BULK PROPERTIES OF CELLULOSE ETHERS ON LIPOLYSIS OF OIL-IN-WATER…
12. March 2016
Cellulose ethers are usually used as secondary emulsifiers. Different types of commercial hydroxypropylmethylcellulose (HPMC) have been used here as the main emulsifier of oil-in-water emulsions to probe their impact on the lipid digestibility under simulated…
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