Pharma Excipients
Cellulose
Spray Drying for Direct Compression of Pharmaceuticals
Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses.…
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Applications of polymer blends in drug delivery
Polymers are essential components of many drug delivery systems and biomedical products. Despite the utility of many currently available polymers, there exists a demand for materials with improved characteristics and functionality. Due to the extensive safety testing required for new excipient…
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Overview of Extensively Employed Polymeric Carriers in Solid Dispersion Technology
Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with interesting physicochemical and thermochemical characteristics available at the disposal of a formulation…
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The progress on sulfhydryl modified polymers with regard to synthesis, characterization and…
The concepts of mucoadhesion and mucoadhesive polymers were introduced in the 20th century, leading to several advantages. These included enhanced drug absorption and extended residence at specific site of action. Polymeric excipients underwent chemical modification with sulfhydryl groups on the…
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Recent advances of nanocellulose in drug delivery systems
Background
Nanocellulose, which possesses great physical, chemical, and biological properties, is a natural polymer derived from widely available native cellulose. It has outstanding properties such as high mechanical strength, stiffness, low weight, biocompatibility, and renewability, which are…
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pH-Responsive Gamma-Irradiated Poly(Acrylic Acid)-Cellulose-Nanocrystal-Reinforced Hydrogels
A pH-sensitive poly(acrylic acid) composite hydrogel was successfully synthesized via gamma irradiation and reinforced with cellulosic materials of different sizes. Cellulose was extracted from rice husks via alkali and bleaching treatment, and an acid hydrolysis treatment was performed to extract…
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Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic…
Functional wound dressing with tailored physicochemical and biological properties is vital for diabetic foot ulcer (DFU) treatment. Our main objective in the current study was to fabricate Cellulose Acetate/Gelatin (CA/Gel) electrospun mat loaded with berberine (Beri) as the DFU-specific wound…
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Electrospinning of natural polymers for the production of nanofibres for wound healing applications
Wound healing is a highly regulated process composed of four overlapping phases: (1) coagulation/haemostasis, (2) inflammation, (3) proliferation and (4) remodelling. Comorbidities such as advanced age, diabetes and obesity can impair natural tissue repair, rendering the wound in a pathological…
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Fully inkjet‐printed glucose assay fabricated on highly porous pigment coating
A simple paper-based microfluidic device, fabricated on a highly porous coating consisting of functionalised calcium carbonate (FCC) pigment and a microfibrillated cellulose (MFC) and/or polyvinyl alcohol (PVOH) binder, was developed for glucose detection. Both the hydrophobic patterns, consisting…
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The Evolution of Cellulose in Tableting Technology
How the evolution from traditional powdered cellulose to microcrystalline cellulose to a new generation of co processed high functionality excipients can benefit tableting processes including continuous manufacturing applications. This shows JRS Pharma in its overview pdf.
Overview
The…
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