Cellulose

Researchers at ETH have produced a gel from cellulose fibres and biodegradable nanoparticles that liquifies when pressed through the nozzle of a 3D printer, but then quickly returns to its original shape. Their invention paves the way for personalised biomaterial implants. Essentially, 3D…
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This study aimed to elucidate the impact of a common anionic surfactant, sodium dodecyl sulfate (SDS), along with hydroxypropyl cellulose (HPC) and Soluplus (Sol) on the release of griseofulvin (GF), a poorly soluble drug, from amorphous solid dispersions (ASDs). Solutions of 2.5% GF and 2.5%–12.5%…
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Powdered cellulose (PC) and microcrystalline cellulose (MCC) show considerable different behavior during wet-extrusion and spheronization. While MCC is an appropriate pelletization aid, PC is not suitable. The differences were explained by either the “molecular-sponge” or the “crystallite-gel”…
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Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of ʹone size fits for allʹ. Using 3D printing, it is possible to design and develop complex dosage forms that can…
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The aim of this work was to develop a mathematical model to estimate the drug release from a conventional single-compartment reservoir pellet and extend its applicability to multi-compartment reservoir pellets. Conventional pellets were prepared by layering the drug onto starter-core then applying…
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The effect of hydroxypropyl methylcellulose (HPMC) and methylcellulose (Methocel® 60 HG) on the dissolution behavior of two cocrystals derived from nitazoxanide (NTZ), viz., nitazoxanide-glutaric acid (NTZ-GLU, 1:1) and nitazoxanide-succinic acid (NTZ-SUC, 2:1), was explored. Powder dissolution…
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Electrospinning (ES) was originally reported in 1899 and the technology has been used since for the fabrication of con- tinuous fibers (Cooley, 1899). Beginning from the 1980s and particularly during the recent decade, the technology has gained increasing attention. Possibly this can be…
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Powdered cellulose (PC) and microcrystalline cellulose (MCC) are common excipients in pharmaceuticals. Recent investigations imply that particle size is the most critical parameter for the different performance in many processes. High-pressure homogenization (HPH) was used to reduce fiber size of…
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Powdered cellulose (PC) and microcrystalline cellulose (MCC) show considerable different behavior during wet-extrusion and spheronization. While MCC is an appropriate pelletization aid, PC is not suitable. The differences were explained by either the “molecular-sponge” or the “crystallite-gel”…
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DuPont aims to help their pharma customers overcome everyday challenges and innovate future solutions. Armed with essential excipients and vital expertise, the broad portfolio is designed to deliver performance and cost advantages in various oral solid dosage forms. Couple that with leading QbD…
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