Pharma Excipients
Cellulose
Nano-crystalline cellulose: Preparation, modification and usage as sustained release drug delivery…
Nano crystalline cellulose (NCC) has gained attention in the pharmaceutical industry owing to its biodegradable nature and high mechanical properties.
In the present work we reported preparation of NCC from cellulose isolated from a bio-waste, its modification and exploration as drug delivery…
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Novel use of insoluble particles as disintegration enhancers for orally disintegrating films
The most important issue in the design of orally disintegrating films (ODFs) is the control of the ODFs' disintegration properties.
A better understanding of the mechanisms of ingredients used to promote or disturb the disintegration time of ODFs would improve the development of ODF formulations.…
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Preparation and evaluation of orally disintegrating film containing donepezil for Alzheimer disease
The present study intended to prepare orally disintegrating film (ODF) containing donepezil (DP) for the treatment of mild to moderate alzheimer disease.
HPMC and HPC, glycerine were used as film forming agents, plasticizer, respectively. The ODFs were prepared by solvent casting method. The…
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Swelling of Zein Matrix Tablets Benchmarked against HPMC and Ethylcellulose: Challenging the Matrix…
Zein is an insoluble, yet swellable, biopolymer that has been extensively studied for its applications in drug delivery. Here, we screened the effect of co-excipients on the swelling and drug release of zein tablets.
All throughout the study the behavior of zein was benchmarked against that of…
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Achieving gastroresistance without coating: Formulation of capsule shells from enteric polymers
Capsules are a widely used oral dosage form due to their simplicity and ease of manufacture.
They are equally popular for both pharmaceutical and nutraceutical products and since they do not need extensive formulation development, it is a dosage form of choice for new drugs undergoing animal or…
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Premium Ethylcellulose Polymer-Based Architectures at Work in Drug Delivery
Premium ethylcellulose polymers are hydrophobic cellulose ether based biomaterials widely employed as biocompatible templates for the design of novel drug delivery systems.
They are classified as United States Food and Drug Administration Generally-Recognized-As-Safe chemical substances and have…
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Development and evaluation of an omeprazole-based delayed-release liquid oral dosage form
Modified-release oral dosage forms are commonly used in pharmaceutics to delay or sustain the release of drugs. Nowadays, they are only marketed as solid dosage forms such as capsules or tablets.
Therefore, the development of a liquid oral dosage form with modified-release properties has been…
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Particle Size-independent Variation of Bulk Excipients
Microcrystalline Cellulose (MCC) has been used as a pharmaceutical excipient for many years, due to its abundance, ease of production and resistance to degradation. As with any excipient, however, variability between batches of supplied material can in turn lead to similar variability in…
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Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters…
Roller compaction is a low cost granulation process which application is sometimes limited by the granular loss of compactability and reduced drug dissolution rate. Hence, the design of a robust manufacturing process is key in order to ensure quality of tablets.
In this study, for ibuprofen…
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Development of a novel method utilising dissolution imaging for the measurement of swelling…
A variety of imaging techniques are currently used within the field of pharmaceutics to help understand and determine a wide range of phenomena associated with drug release from hydrophilic matrix tablets.
This work for the first time aims at developing an appropriate testing imaging methodology…
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