Pharma Excipients
Calcium CarbonateCMC and Croscarmellose Sodium
Risk Assessment and QbD-Based Optimization of Sorafenib Tosylate Colon Targeted Bilayer Tablet: In…
The employment of site-specific administration in colon is a promising technique to improve efficacy and reduce systemic side effects of anticancer medications used in colorectal cancer. However, the physiology of the gastrointestinal tract and colonic environment limit the efficient delivery of…
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Formulation development of loratadine immediate-release tablets using hot-melt extrusion and 3D…
The main goal of this study was to develop immediate release Fused Deposition Modeling (FDM) 3D printed loratadine tablets using hot-melt extrusion (HME) filaments. Loratadine was used as a model drug with 10% (w/w) drug loading. Ten different formulations were prepared using Crospovidone and…
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Effect of carboxymethyl cellulose and polyvinyl alcohol on the cracking of particulate coating…
We investigated the effect of polymers on the cracking of particulate coating layers. Carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVA) were used as contrasting polymer additives due to their different surface charges and film characteristics. Drying stress that generates cracking in…
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Identification of Critical Factors Influencing the In-Vitro Dissolution of Bicalutamide Tablets…
This study was aimed to utilize the Moisture Activated Dry Granulation (MADG) technique to formulate Bicalutamide tablet and identify critical factors influencing its dissolution. The Bicalutamide inclusion complex was formed using the kneading method. Aeroperl 300 was selected as an adsorbent,…
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Polymer selection to increase in vitro supersaturation generated by lamotrigine nicotinamide…
Cocrystals can improve drug dissolution by generating supersaturated drug delivery systems. However, supersaturation is a high-energetic state with a tendency to precipitate. Polymers are used as precipitation inhibitors to inhibit nucleation or crystal growth. Our aim was to evaluate the influence…
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Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical…
Capping is a common defect that can occur during the manufacturing of pharmaceutical tablets. Several studies showed that decreasing the unloading speed of the manufacturing cycle plays a role in the occurrence of such defects. Following this idea, we study in this work the influence of the…
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Matrix Effects on the Performance of Disintegrants in Hydrophobic Tablets – Scientific Poster
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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Drug-loaded mesoporous silica on carboxymethyl cellulose hydrogel: Development of innovative 3D…
3D printing has been explored as an emerging technology for the development of versatile and printable materials for drug delivery. However, the alliance of 3D printing and nanomaterials has, to date, been little explored in pharmaceutics. Herein, a mesoporous silica with nanostructured pores,…
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The Effect of Humidity on Tablet Surfaces Containing Different Types of Superdisintegrants –…
The 12th APV PBP World Meeting took place from 28 - 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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Investigation on in-vitro Dissolution and Tableting Properties Enhancement of Etodolac using…
Objectives: The objective of present study was to improve dissolution rate with tableting properties of BCS class II drug Etodolac, by melt granulation and sublimation techniques.
Materials and Methods: The granules of etodolac were formulated using Gelucire 50/13. The surface adsorbent Aerosil…
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