Pharma Excipients
Calcium CarbonateCMC and Croscarmellose Sodium
Application of Design Space, Uncertainty, and Risk Profile Strategies to the Development and…
Background: Counterfeit medicines are an increasing scourge that are difficult to identify and they have become industrialized and widespread through highly organized illegal channels.
Objective: This research aims to develop a robust method to determine four phosphodiesterase type-5 inhibitors…
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Orodispersible Film Loaded with Enterococcus faecium CRL183 Presents Anti-Candida albicans Biofilm…
Background: Probiotic bacteria have been emerging as a trustworthy choice for the prevention and treatment of Candida spp. infections. This study aimed to develop and characterize an orodispersible film (ODF) for delivering the potentially probiotic Enterococcus faecium CRL 183 into the oral cavity,…
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Investigating the Influence of Excipients on the Stability of Levothyroxine Sodium Pentahydrate
A range of tablet excipients were evaluated for their influence on the physical form and chemical stability of levothyroxine sodium pentahydrate (LSP; C15H10I4NNaO4·5H2O). LSP–excipient binary powder blends were stored under two conditions: (a) in hermetically sealed containers at 40 °C and (b) at…
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An ultrasonographic assisted investigation for the enhancement of duodenal/cecal motility of…
Gastrointestinal (GI) disorders affect millions of people and are considered a major cause of global morbidity. Mosapride citrate (MOS) is a prokinetic agent with antiemetic effect. The drug suffers from poor bioavailability that is induced by its low solubility. The present study aimed to enhance…
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Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of…
The current study evaluated the effect of location and amount of various superdisintegrants on the properties of tablets made by twin-screw melt granulation (TSMG). Sodium-croscarmellose (CCS), crospovidone (CPV), and sodium starch glycolate (SSG) were used in various proportions intra- and…
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Functionality and Acceptance of the EsoCap System – A Novel Film-Based Drug Delivery…
There are no methods for specific local application of active substances to the mucosa of the esophagus to treat eosinophilic esophagitis or other esophageal diseases. This publication describes the principal in vivo functionality and acceptance of a novel modular drug delivery concept, called…
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Rheological properties of cellulosic thickeners in hydro-alcoholic media: the science behind the…
Cellulosic-based thickeners are commonly used in the preparation of hydro-alcoholic hand sanitisers. Yet, little is known about the behaviour of these polymeric dispersions in hydro-alcoholic mixtures. Here, we studied the dispersion ability and rheology of hydroxyethyl cellulose, hydroxypropyl…
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Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in…
Targeting celecoxib to the ileo-colonic region could be beneficial for the treatment and prevention of colon cancer. Ileo-colonic targeting can be achieved by using pH-dependent coating systems such as ColoPulse. Celecoxib has poor aqueous solubility, which may jeopardize optimal treatment.…
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Developing and evaluation of orodispersible tablets containing caffeine
Starting from the premise that a reduced number of active pharmaceutical ingredients (APIs) are used to treat hypotension, the aim of this study consisted of developing new formulations of caffeine-orodispersible tablets (CAF- ODTs). The formulation variables were the type of disintegrant…
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Tablet disintegration performance: Effect of compression pressure and storage conditions on surface…
The disintegration process of pharmaceutical tablets is a crucial step in the oral delivery of a drug. Tablet disintegration does not only refer to the break up of the interparticle bonds, but also relates to the liquid absorption and swelling behaviour of the tablet.
This study demonstrates the…
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