Pharma Excipients
Calcium CarbonateCMC and Croscarmellose Sodium
Amorphous Solid Dispersions in Early Stage of Formulation Development: Predicting Excipient…
Excipients play an important role in the formulation of dosage forms and can be used to improve the bioavailability of a drug through physical interactions that alter the rate of dissolution of a drug. The objective of this study was to predict the effect of formulation on the dissolution rate of a…
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Effect of common excipients on intestinal drug absorption in Wistar rats
The aim of the present paper is to study the effect of common excipients on the permeability of atenolol (as drug absorbed mainly by passive diffusion) and rhodamine (as P-Glycoprotein substrate). Apparent permeability was measured by in situ perfusion method in Wistar rats using the Closed loop…
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Temperature: an overlooked factor in tablet disintegration
Disintegration is the first event in the bioavailability cascade after the ingestion of immediate release tablets. Although the influence of various physico-chemical parameters of media on tablet disintegration has been investigated in depth, the role of temperature has received much less attention.…
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In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet…
Wetting is the initial stage of wet granulation processes during which the first contact between the powder and the liquid occurs. Wetting is a critical step to allow granule growth and consolidation, but also to ensure uniform active pharmaceutical ingredient (API) distribution over all granule…
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Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets
This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of…
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Functionality of disintegrants with different mechanisms after roll compaction
The aim of this study was to investigate the functionality of two disintegrants (crospovidone and croscarmellose sodium) in tablet formulations processed via roll compaction and subsequent tableting. The influence of different fillers and the effect of sodium lauryl sulfate on the disintegration…
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Ac-Di-Sol® SD-711 Superdisintegrant – Whitepaper
DuPont’s portfolio of Pharma solutions and formulation and process expertise drive improved product, process and cost performance based on real-world experience. Using Ac-Di-Sol® SD-711 at lower levels and earlier in the development process can help reduce cost, complexity, and working capital by…
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Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet…
Fast disintegrating tablets have commonly been used for fast oral drug delivery to patients with swallowing difficulties. The different characteristics of the pore structure of such formulations influence the liquid transport through the tablet and hence affect the disintegration time and the…
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Drug Delivery Strategies for Poorly Water-Soluble Silymarin
Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from milk thistle (Silybum marianum) seeds, is gaining an increasingly widespread clinical consensus as a natural remedy in the treatment of numerous chronic liver diseases such as cirrhosis and hepatocellular…
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Solidification of SMEDDS by fluid bed granulation and manufacturing of fast drug release tablets
Solidification of self-microemulsifying drug delivery systems (SMEDDS) is a rising experimental field with important potential for pharmaceutical industry, however fluid-bed granulation with SMEDDS is yet an unexplored solidification technique. The aim of the study was to solidify carvedilol-loaded…
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